exRNAdisease

Entry Detail

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General Information

Database ID: exR0356404 RNA Name: hsa-miR-143-3p RNA Type: miRNA Chromosome: chr5 Starnd: + Coordinate: Start Site(bp): 149428978 End Site(bp): 149428998 External Links: hsa-miR-143-3p

Disease Information

Disease Name: Breast Cancer Disease Category: Cancers MeSH ID: D001943 Type: Neoplasms/Breast Neoplasms Alias: Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast

Expression Detail

GEO ID: GSE98181 Description: Circulating miRNA profiles from serum of women at high-risk for breast cancer Experimental Design: Cancer vs Control Case Disease Type: Breast Cancer Case Disease SubType: NA Case Sample: Breast Cancer Control Sample: Healthy Number of Case: 24 Number of Control: 24 Number of Samples: 48

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ACVR1B chr12 51951699 51997078 + BTF3L4 chr1 52056199 52090716 + BTG2 chr1 203305491 203309602 + CAPZB chr1 19338775 19485539 - CDK6 chr7 92604921 92836594 - CELSR2 chr1 109249539 109275751 + CIT chr12 119685791 119877320 - DEGS1 chr1 224175756 224193441 + DYRK1B chr19 39825350 39834201 - EFNA3 chr1 155078837 155087538 + FOSL2 chr2 28392448 28417317 + IGFBP5 chr2 216672105 216695549 - KRIT1 chr7 92198969 92246166 - MAP3K3 chr17 63622415 63696303 + NES chr1 156668763 156677407 - PACS1 chr11 66070272 66244744 + PATL1 chr11 59636716 59669037 - PNKD chr2 218270392 218346793 + RFWD3 chr16 74621399 74666877 - SLC7A11 chr4 138164097 138242349 - SON chr21 33543038 33577481 + STARD4 chr5 111496033 111512590 - STMN3 chr20 63639705 63657682 - TATDN2 chr3 10248023 10281218 + TFPI chr2 187464230 187565760 - TIGD5 chr8 143597831 143603224 + VPS37C chr11 61130257 61161615 - WSB1 chr17 27294076 27315926 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001247 chr22 46125304 46136418 + hsa_circ_0000711 chr16 68155889 68160513 + hsa_circ_0000431 chr12 102301963 102308010 + hsa_circ_0001168 chr20 47691321 47707559 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC009022.1 chr16 69976297 70065948 - AC091564.7 chr11 6610883 6616594 - AC245884.8 chr19 54438665 54439544 - DHRS4-AS1 chr14 23938219 24052555 - LINC00667 chr18 5237826 5290608 + LZTS1-AS1 chr8 20275773 20290458 + MALAT1 chr11 65497688 65506516 + MCM3AP-AS1 chr21 46229196 46259390 + OIP5-AS1 chr15 41283990 41309737 + Display:

Experiment Detail

GEO ID: GSE98181 Sample Source: Blood Source Fraction: Serum Platform: GPL21572 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2546 Sample treatment protocol: Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes. RNA Extract protocol: RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water. RNA library preparation protocol: Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.

Reference

PMID: 29348816 Title: Development of a predictive miRNA signature for breast cancer risk among high-risk women. Author: Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME Journal: Oncotarget. 2017 Nov 28;8(68):112170-112183. Description: We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.