exRNAdisease

General Information

Database ID:

exR0356414

RNA Name:

hsa-miR-146a-5p

RNA Type:

miRNA

Chromosome:

chr5

Starnd:

Coordinate:

Start Site(bp):

160485372

End Site(bp):

160485393

External Links:

Disease Information

Disease Name:	Breast Cancer
Disease Category:	Cancers
MeSH ID:	D001943
Type:	Neoplasms/Breast Neoplasms
Alias:	Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast

Expression Detail

GEO ID:	GSE98181
Description:	Circulating miRNA profiles from serum of women at high-risk for breast cancer
Experimental Design:	Cancer vs Control
Case Disease Type:	Breast Cancer
Case Disease SubType:	NA
Case Sample:	Breast Cancer
Control Sample:	Healthy
Number of Case:	24
Number of Control:	24
Number of Samples:	48

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
ALDOA	chr16	30064164	30070457	+
ATP6V0D1	chr16	67438014	67481181	-
FXYD3	chr19	35115879	35124324	+
GATAD1	chr7	92447482	92460075	+
HYOU1	chr11	119044188	119057227	-
JPT2	chr16	1678256	1702280	+
NFIX	chr19	12995608	13098796	+
RNF169	chr11	74748849	74842413	+
SKA2	chr17	59109857	59155260	-
SS18	chr18	26016253	26091217	-
TACC1	chr8	38728186	38853028	+
WDR45B	chr17	82614562	82648553	-
ZNF512B	chr20	63956704	63969930	-
ZNRF3	chr22	28883572	29057488	+
APEH	chr3	49674014	49683971	+
DCAF1	chr3	51395867	51500002	-
GNAS	chr20	58839718	58911192	+
HSP90AA1	chr14	102080738	102139699	-
KDM1A	chr1	23019443	23083689	+
MARCKS	chr6	113857345	113863475	+
NDUFS2	chr1	161197104	161214395	+
RBBP7	chrX	16839283	16870414	-
RPL9	chr4	39452521	39458949	-
SAP18	chr13	21140514	21149084	+
SLC25A5	chrX	119468422	119471396	+
SPAG5	chr17	28577565	28599025	-

miRNA targets:

circRNA targets:

circRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa_circ_0000418	chr12	69983264	69985939	+
hsa_circ_0001361	chr3	171830241	171851336	+
hsa_circ_0000943	chr19	47421744	47440665	+
hsa_circ_0000799	chr17	65941524	65972074	+

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
KCNQ1OT1	chr11	2608328	2699994	-
MALAT1	chr11	65497688	65506516	+
NEAT1	chr11	65422774	65445540	+
SNHG16	chr17	76557764	76565348	+
XIST	chrX	73820649	73852723	-

Display:

Experiment Detail

GEO ID:	GSE98181
Sample Source:	Blood
Source Fraction:	Serum
Platform:	GPL21572
Method:	Microarray
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	2546
Sample treatment protocol:	Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes.
RNA Extract protocol:	RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water.
RNA library preparation protocol:	Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.

Reference

PMID:	29348816
Title:	Development of a predictive miRNA signature for breast cancer risk among high-risk women.
Author:	Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME
Journal:	Oncotarget. 2017 Nov 28;8(68):112170-112183.
Description:	We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.