Entry Detail



General Information

Database ID:exR0356419
RNA Name:hsa-miR-147a
RNA Type:miRNA
Chromosome:chr9
Starnd:-
Coordinate:
Start Site(bp):120244985End Site(bp):120245004
External Links:hsa-miR-147a



Disease Information

Disease Name:Breast Cancer
Disease Category:Cancers
MeSH ID:D001943
Type:Neoplasms/Breast Neoplasms
Alias:Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast



Expression Detail

GEO ID:GSE98181
Description:Circulating miRNA profiles from serum of women at high-risk for breast cancer
Experimental Design:Cancer vs Control
Case Disease Type:Breast Cancer
Case Disease SubType:NA
Case Sample:Breast Cancer
Control Sample:Healthy
Number of Case:24
Number of Control:24
Number of Samples:48





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
TWF1
chr12
43793723
43806375
-
GLYR1
chr16
4803203
4847288
-
PLPP6
chr9
4662294
4665258
+
USP37
chr2
218450251
218568351
-
CTSD
chr11
1752755
1764573
-
NUP58
chr13
25301556
25349800
+
JARID2
chr6
15246069
15522042
+
SCARB1
chr12
124776856
124882668
-
MGRN1
chr16
4616493
4690974
+
CRKL
chr22
20917407
20953747
+
SIPA1L3
chr19
37907208
38208369
+
TIMP3
chr22
32801701
32863043
+
SNAI2
chr8
48917598
48921740
-
FAM13A
chr4
88725955
89111398
-
ZNF618
chr9
113876282
114056591
+
SMIM12
chr1
34712737
34859755
-
CCND1
chr11
69641156
69654474
+
FOXK2
chr17
82519713
82644662
+
SLC7A1
chr13
29509414
29595688
-
ATP11A
chr13
112690329
112887168
+
PSME3
chr17
42824385
42843760
+
WIZ
chr19
15419978
15449956
-
PURA
chr5
140107777
140125619
+
STARD7
chr2
96184859
96208825
-
OSBPL9
chr1
51577179
51798427
+
PIK3C2A
chr11
17077730
17207983
-
NKIRAS2
chr17
42011382
42025644
+
LIMD1
chr3
45555394
45686341
+
TNFRSF10B
chr8
23020133
23069031
-
ARHGAP35
chr19
46860997
47005077
+
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000816
chr17
80521229
80526077
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC004951.4
chr7
43951910
44019151
-
AC010442.1
chr5
466124
473098
-
AL355987.2
chr9
136800366
136829466
+
DSCAM-AS1
chr21
40383083
40385358
+
KCNQ1OT1
chr11
2608328
2699994
-
MIR503HG
chrX
134543119
134546642
-
NEAT1
chr11
65422774
65445540
+
POLR2J4
chr7
43940895
44019175
-
Display:



Experiment Detail

GEO ID:GSE98181
Sample Source:Blood
Source Fraction:Serum
Platform:GPL21572
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2546
Sample treatment protocol:Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes.
RNA Extract protocol:RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water.
RNA library preparation protocol:Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.



Reference

PMID:29348816
Title:Development of a predictive miRNA signature for breast cancer risk among high-risk women.
Author:Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME
Journal:Oncotarget. 2017 Nov 28;8(68):112170-112183.
Description:We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.