Entry Detail



General Information

Database ID:exR0356443
RNA Name:hsa-miR-155-5p
RNA Type:miRNA
Chromosome:chr21
Starnd:+
Coordinate:
Start Site(bp):25573983End Site(bp):25574006
External Links:hsa-miR-155-5p



Disease Information

Disease Name:Breast Cancer
Disease Category:Cancers
MeSH ID:D001943
Type:Neoplasms/Breast Neoplasms
Alias:Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast



Expression Detail

GEO ID:GSE98181
Description:Circulating miRNA profiles from serum of women at high-risk for breast cancer
Experimental Design:Cancer vs Control
Case Disease Type:Breast Cancer
Case Disease SubType:NA
Case Sample:Breast Cancer
Control Sample:Healthy
Number of Case:24
Number of Control:24
Number of Samples:48





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
TSC22D4
chr7
100463359
100479232
-
ACOT7
chr1
6264269
6394391
-
MRFAP1
chr4
6640091
6642745
+
SH3KBP1
chrX
19533977
19887600
-
NUFIP2
chr17
29255839
29294148
-
CENPM
chr22
41938737
41947152
-
SP100
chr2
230415942
230545606
+
ARL3
chr10
102673731
102714397
-
JAK1
chr1
64833229
65067754
-
LAPTM4A
chr2
20032650
20051628
-
SOD2
chr6
159669069
159745186
-
HNRNPLL
chr2
38561969
38603586
-
LCP1
chr13
46125920
46211871
-
AICDA
chr12
8602170
8612867
-
CD52
chr1
26317958
26320523
+
MFSD9
chr2
102714630
102736888
-
NDUFA4
chr7
10931943
10940153
-
CHEK2
chr22
28687743
28742422
-
ZMYM5
chr13
19823482
19863649
-
PGLS
chr19
17511636
17521288
+
CCNB1
chr5
69167135
69178245
+
IL2RG
chrX
71107404
71112108
-
CXXC1
chr18
50282343
50288304
-
RBM38
chr20
57391396
57409333
+
CFL1
chr11
65823022
65862026
-
PPM1B
chr2
44167969
44244384
+
ZFP36
chr19
39406847
39409412
+
FTL
chr19
48965309
48966879
+
ERH
chr14
69380128
69398299
-
VPS18
chr15
40894450
40903975
+
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000642
chr15
80390757
80415142
+
hsa_circ_0000892
chr19
11941431
12014514
+
hsa_circ_0001046
chr2
97024782
97033111
+
hsa_circ_0000643
chr15
80412669
80415142
+
hsa_circ_0000698
chr16
47531309
47549512
+
hsa_circ_0001146
chr20
34241449
34246936
-
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC021078.1
chr5
149494314
149504670
-
AC090198.1
chr8
124488510
124491643
+
AC245033.4
chr15
82533175
82540008
-
AL022311.1
chr22
37876148
37895563
+
ELOA-AS1
chr1
23706901
23778296
-
GABPB1-AS1
chr15
50354959
50372202
+
LINC00240
chr6
26956932
27059749
+
LINC01772
chr1
16460948
16468481
+
MALAT1
chr11
65497688
65506516
+
MIR155HG
chr21
25561909
25575168
+
MIR17HG
chr13
91347820
91354579
+
NORAD
chr20
36045618
36051018
-
OIP5-AS1
chr15
41283990
41309737
+
SNHG5
chr6
85650491
85678932
-
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE98181
Sample Source:Blood
Source Fraction:Serum
Platform:GPL21572
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2546
Sample treatment protocol:Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes.
RNA Extract protocol:RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water.
RNA library preparation protocol:Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.



Reference

PMID:29348816
Title:Development of a predictive miRNA signature for breast cancer risk among high-risk women.
Author:Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME
Journal:Oncotarget. 2017 Nov 28;8(68):112170-112183.
Description:We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.