exRNAdisease

Entry Detail

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General Information

Database ID: exR0356471 RNA Name: hsa-miR-185-5p RNA Type: miRNA Chromosome: chr22 Starnd: + Coordinate: Start Site(bp): 20033153 End Site(bp): 20033174 External Links: hsa-miR-185-5p

Disease Information

Disease Name: Breast Cancer Disease Category: Cancers MeSH ID: D001943 Type: Neoplasms/Breast Neoplasms Alias: Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast

Expression Detail

GEO ID: GSE98181 Description: Circulating miRNA profiles from serum of women at high-risk for breast cancer Experimental Design: Cancer vs Control Case Disease Type: Breast Cancer Case Disease SubType: NA Case Sample: Breast Cancer Control Sample: Healthy Number of Case: 24 Number of Control: 24 Number of Samples: 48

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand TFAP2A chr6 10393186 10419659 - SSH2 chr17 29625938 29930276 - ZBTB4 chr17 7459366 7484263 - CTSA chr20 45890144 45898820 + TSPAN14 chr10 80454166 80533124 + ACVR1B chr12 51951699 51997078 + GRB2 chr17 75318076 75405709 - RAB5A chr3 19947097 19985175 + RAB40C chr16 589357 629272 + VPS37B chr12 122865330 122896127 - SLC29A1 chr6 44219553 44234142 + NDRG1 chr8 133237171 133302022 - HDLBP chr2 241227264 241317061 - RSU1 chr10 16590611 16817463 - HADHA chr2 26190635 26244672 - VPS4A chr16 69311350 69326939 + IGF2BP1 chr17 48997385 49056145 + NF1 chr17 31094927 31382116 + SMAD3 chr15 67063763 67195169 + ORAI1 chr12 121626550 121642677 + ADGRG1 chr16 57610652 57665580 + TNRC6B chr22 40044817 40335808 + ZMIZ1 chr10 79068966 79316528 + GOLGA1 chr9 124878275 124948492 - ZBTB38 chr3 141324213 141449792 + SLC29A2 chr11 66362521 66372214 - GATAD2B chr1 153789030 153923360 - GBA2 chr9 35736866 35749228 - OTUD4 chr4 145110838 145180589 - FAM234A chr16 234521 272183 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001658 chr6 157357968 157406039 + hsa_circ_0000711 chr16 68155889 68160513 + hsa_circ_0001168 chr20 47691321 47707559 + hsa_circ_0001146 chr20 34241449 34246936 - hsa_circ_0001164 chr20 45891031 45923523 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC007952.4 chr17 19112000 19112636 - AC008040.1 chr3 169939353 169966734 - AC021092.1 chr19 44103007 44113183 - LINC01278 chrX 63222993 63561095 - MALAT1 chr11 65497688 65506516 + MIR137HG chr1 97933474 98049863 - MIR663AHG chr20 26167817 26251546 - NEAT1 chr11 65422774 65445540 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE98181 Sample Source: Blood Source Fraction: Serum Platform: GPL21572 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2546 Sample treatment protocol: Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes. RNA Extract protocol: RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water. RNA library preparation protocol: Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.

Reference

PMID: 29348816 Title: Development of a predictive miRNA signature for breast cancer risk among high-risk women. Author: Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME Journal: Oncotarget. 2017 Nov 28;8(68):112170-112183. Description: We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.