exRNAdisease

Entry Detail

---



General Information

Database ID: exR0356479 RNA Name: hsa-miR-18a-5p RNA Type: miRNA Chromosome: chr13 Starnd: + Coordinate: Start Site(bp): 91350756 End Site(bp): 91350778 External Links: hsa-miR-18a-5p

Disease Information

Disease Name: Breast Cancer Disease Category: Cancers MeSH ID: D001943 Type: Neoplasms/Breast Neoplasms Alias: Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast

Expression Detail

GEO ID: GSE98181 Description: Circulating miRNA profiles from serum of women at high-risk for breast cancer Experimental Design: Cancer vs Control Case Disease Type: Breast Cancer Case Disease SubType: NA Case Sample: Breast Cancer Control Sample: Healthy Number of Case: 24 Number of Control: 24 Number of Samples: 48

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand PATZ1 chr22 31325804 31346346 - TUBA4A chr2 219249710 219278170 - SURF4 chr9 133361450 133376166 - DDX5 chr17 64498254 64508199 - SND1 chr7 127652194 128092609 + HIF1AN chr10 100529072 100559998 + SIK2 chr11 111602449 111730855 + FKBP1A chr20 1368978 1393172 - USP10 chr16 84699978 84779922 + PARL chr3 183829271 183884933 - ASF1B chr19 14119512 14136613 - PRPF38B chr1 108692310 108702928 + ADAT2 chr6 143422832 143450695 - ZNF12 chr7 6688433 6706947 - DNAJC9 chr10 73183362 73247255 - AC131160.1 chr3 183815568 183884889 - ACSS2 chr20 34872146 34927962 + MRPS18A chr6 43671303 43687791 - XRCC6 chr22 41621119 41664048 + ROMO1 chr20 35699272 35700984 + PEX5 chr12 7188685 7218574 + NDUFV2 chr18 9102630 9134345 + UBE2Z chr17 48908407 48929056 + NOP58 chr2 202265736 202303661 + RNF4 chr4 2462220 2625320 + CHD1 chr5 98853985 98928957 - ATP2B1 chr12 89588049 89709300 - SLC41A1 chr1 205789094 205813748 - NCDN chr1 35557473 35567274 + HMGCS1 chr5 43287470 43313512 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000712 chr16 68208276 68225678 + hsa_circ_0001186 chr21 35475133 35475818 + hsa_circ_0001247 chr22 46125304 46136418 + hsa_circ_0000921 chr19 30476129 30477324 + hsa_circ_0000943 chr19 47421744 47440665 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC073896.4 chr12 56162359 56190284 - AC093010.3 chr3 114314501 114329714 - AC145207.5 chr17 81878425 81881106 - AL162171.3 chr14 88589231 88592408 + AP005263.1 chr18 9102736 9254346 + CASC2 chr10 118046279 118210158 + GAS5 chr1 173858559 173868882 - NEAT1 chr11 65422774 65445540 + SNHG1 chr11 62851984 62855953 - SNHG15 chr7 44983023 44986961 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE98181 Sample Source: Blood Source Fraction: Serum Platform: GPL21572 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2546 Sample treatment protocol: Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes. RNA Extract protocol: RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water. RNA library preparation protocol: Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.

Reference

PMID: 29348816 Title: Development of a predictive miRNA signature for breast cancer risk among high-risk women. Author: Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME Journal: Oncotarget. 2017 Nov 28;8(68):112170-112183. Description: We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.