exRNAdisease

General Information

Database ID:

exR0356514

RNA Name:

hsa-miR-196b-5p

RNA Type:

miRNA

Chromosome:

chr7

Starnd:

Coordinate:

Start Site(bp):

27169528

End Site(bp):

27169549

External Links:

Disease Information

Disease Name:	Breast Cancer
Disease Category:	Cancers
MeSH ID:	D001943
Type:	Neoplasms/Breast Neoplasms
Alias:	Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast

Expression Detail

GEO ID:	GSE98181
Description:	Circulating miRNA profiles from serum of women at high-risk for breast cancer
Experimental Design:	Cancer vs Control
Case Disease Type:	Breast Cancer
Case Disease SubType:	NA
Case Sample:	Breast Cancer
Control Sample:	Healthy
Number of Case:	24
Number of Control:	24
Number of Samples:	48

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
ACP1	chr2	264140	278283	+
ARHGAP28	chr18	6729718	6915716	+
ARL5A	chr2	151788984	151828492	-
BLOC1S6	chr15	45587214	45615945	+
C15orf41	chr15	36579626	36810248	+
C19orf53	chr19	13774456	13778773	+
COL6A2	chr21	46098112	46132848	+
CS	chr12	56271699	56300391	-
FAM222B	chr17	28755978	28855232	-
HOXA7	chr7	27153716	27157936	-
IGDCC3	chr15	65327127	65378002	-
IGF2BP1	chr17	48997385	49056145	+
LDOC1	chrX	141111605	141177129	-
LYSMD2	chr15	51723011	51751585	-
PDE6D	chr2	231732433	231786272	-
PFKFB3	chr10	6144934	6254644	+
TMEM161B	chr5	88189633	88269476	-
XPO4	chr13	20777329	20903048	-
XPO6	chr16	28097979	28211920	-
ZMYND11	chr10	134465	254637	+

miRNA targets:

circRNA targets:

circRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa_circ_0001454	chr4	154524454	154533552	+
hsa_circ_0000095	chr1	95609446	95616975	+
hsa_circ_0001522	chr5	122881110	122893258	+
hsa_circ_0000799	chr17	65941524	65972074	+

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC005034.3	chr2	75697583	75697996	+
ARHGAP27P1-BPTFP1-KPNA2P3	chr17	64749663	64781707	-
FGD5-AS1	chr3	14920347	14948424	-
GAS5	chr1	173858559	173868882	-
H19	chr11	1995176	2001470	-
KCNQ1OT1	chr11	2608328	2699994	-
NEAT1	chr11	65422774	65445540	+
SNHG16	chr17	76557764	76565348	+
TUG1	chr22	30969245	30979395	+
XIST	chrX	73820649	73852723	-

Display:

Experiment Detail

GEO ID:	GSE98181
Sample Source:	Blood
Source Fraction:	Serum
Platform:	GPL21572
Method:	Microarray
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	2546
Sample treatment protocol:	Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes.
RNA Extract protocol:	RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water.
RNA library preparation protocol:	Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.

Reference

PMID:	29348816
Title:	Development of a predictive miRNA signature for breast cancer risk among high-risk women.
Author:	Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME
Journal:	Oncotarget. 2017 Nov 28;8(68):112170-112183.
Description:	We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.