exRNAdisease

General Information

Database ID:

exR0356528

RNA Name:

hsa-miR-19b-3p

RNA Type:

miRNA

Chromosome:

chr13

Starnd:

Coordinate:

Start Site(bp):

91351245

End Site(bp):

91351267

External Links:

Disease Information

Disease Name:	Breast Cancer
Disease Category:	Cancers
MeSH ID:	D001943
Type:	Neoplasms/Breast Neoplasms
Alias:	Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast

Expression Detail

GEO ID:	GSE98181
Description:	Circulating miRNA profiles from serum of women at high-risk for breast cancer
Experimental Design:	Cancer vs Control
Case Disease Type:	Breast Cancer
Case Disease SubType:	NA
Case Sample:	Breast Cancer
Control Sample:	Healthy
Number of Case:	24
Number of Control:	24
Number of Samples:	48

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
BCL7A	chr12	122019422	122062044	+
UBA1	chrX	47190861	47215128	+
RPS23	chr5	82273320	82278396	-
ALDH3A2	chr17	19648136	19685760	+
MEF2D	chr1	156463727	156500779	-
TBC1D25	chrX	48539714	48562609	+
ANAPC16	chr10	72216000	72235860	+
PYGB	chr20	25248085	25298012	+
CASP2	chr7	143288215	143307696	+
TUB	chr11	8019244	8106112	+
SRSF6	chr20	43457893	43466046	+
CAMTA1	chr1	6785454	7769706	+
PMPCB	chr7	103297435	103329511	+
RFX1	chr19	13961530	14007039	-
BTBD7	chr14	93237550	93333092	-
ZNF397	chr18	35241030	35267133	+
F13A1	chr6	6144084	6321013	-
DNAJC16	chr1	15526813	15592379	+
HOMER1	chr5	79372636	79514134	-
REV1	chr2	99400475	99490035	-
RAB18	chr10	27504174	27542237	+
TBL1X	chrX	9463295	9741037	+
MTREX	chr5	55307989	55425579	+
PTPN21	chr14	88465778	88555007	-
EIF4A2	chr3	186783205	186789897	+
PATL1	chr11	59636716	59669037	-
ST3GAL5	chr2	85837120	85905199	-
USP14	chr18	158383	214629	+
CLDN6	chr16	3014712	3020071	-
COPB1	chr11	14443440	14500027	-

miRNA targets:

circRNA targets:

circRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa_circ_0001454	chr4	154524454	154533552	+
hsa_circ_0001186	chr21	35475133	35475818	+
hsa_circ_0000384	chr12	27867712	27877119	+
hsa_circ_0001605	chr6	42903447	42905047	+
hsa_circ_0000155	chr1	168007608	168014465	+
hsa_circ_0001495	chr5	68470703	68471364	+
hsa_circ_0000943	chr19	47421744	47440665	+
hsa_circ_0001164	chr20	45891031	45923523	-

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC005394.2	chr19	28435388	28727680	-
AC010997.3	chr10	75279726	75401246	-
AC011498.2	chr19	4447304	4448217	+
AC011503.2	chr19	23927788	23929287	+
AC021078.1	chr5	149494314	149504670	-
AC135050.6	chr16	31122235	31124064	+
AL049840.4	chr14	103694516	103695050	-
AL158206.1	chr9	19453209	19455173	+
AL158825.2	chr9	75009828	75016036	-
H19	chr11	1995176	2001470	-
HAGLR	chr2	176164051	176188958	-
LAMTOR5-AS1	chr1	110347116	110443817	+
LINC00667	chr18	5237826	5290608	+
MCM3AP-AS1	chr21	46229196	46259390	+
NEAT1	chr11	65422774	65445540	+
SNHG20	chr17	77086716	77099902	+
XIST	chrX	73820649	73852723	-

Display:

Experiment Detail

GEO ID:	GSE98181
Sample Source:	Blood
Source Fraction:	Serum
Platform:	GPL21572
Method:	Microarray
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	2546
Sample treatment protocol:	Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes.
RNA Extract protocol:	RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water.
RNA library preparation protocol:	Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.

Reference

PMID:	29348816
Title:	Development of a predictive miRNA signature for breast cancer risk among high-risk women.
Author:	Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME
Journal:	Oncotarget. 2017 Nov 28;8(68):112170-112183.
Description:	We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.