exRNAdisease

General Information

Database ID:

exR0356529

RNA Name:

hsa-miR-200a-3p

RNA Type:

miRNA

Chromosome:

chr1

Starnd:

Coordinate:

Start Site(bp):

1167916

End Site(bp):

1167937

External Links:

Disease Information

Disease Name:	Breast Cancer
Disease Category:	Cancers
MeSH ID:	D001943
Type:	Neoplasms/Breast Neoplasms
Alias:	Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast

Expression Detail

GEO ID:	GSE98181
Description:	Circulating miRNA profiles from serum of women at high-risk for breast cancer
Experimental Design:	Cancer vs Control
Case Disease Type:	Breast Cancer
Case Disease SubType:	NA
Case Sample:	Breast Cancer
Control Sample:	Healthy
Number of Case:	24
Number of Control:	24
Number of Samples:	48

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
ANP32E	chr1	150218417	150236156	-
ARPC5	chr1	183620846	183635783	-
GALNT10	chr5	154190730	154420984	+
KRT10	chr17	40818117	40822614	-
PDHA1	chrX	19343893	19361718	+
PIGW	chr17	36534987	36539310	+
QKI	chr6	163414000	163578592	+
QSER1	chr11	32892820	32993316	+
RMND5A	chr2	86720291	86778041	+
TNRC6B	chr22	40044817	40335808	+
C6orf62	chr6	24704861	24719998	-
PLAG1	chr8	56160909	56211324	-

miRNA targets:

circRNA targets:

circRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa_circ_0001329	chr3	119219541	119222868	+
hsa_circ_0001376	chr3	194169185	194175121	-

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC016831.1	chr7	130876809	130913310	-
AC023509.1	chr12	53441741	53467528	+
AC234582.1	chr1	155195004	155205495	+
AL049840.4	chr14	103694516	103695050	-
MALAT1	chr11	65497688	65506516	+
MIR29B2CHG	chr1	207801518	207879115	-
NEAT1	chr11	65422774	65445540	+
OIP5-AS1	chr15	41283990	41309737	+
PINK1-AS	chr1	20642657	20652193	-
SNHG15	chr7	44983023	44986961	-
SNHG16	chr17	76557764	76565348	+
XIST	chrX	73820649	73852723	-

Display:

Experiment Detail

GEO ID:	GSE98181
Sample Source:	Blood
Source Fraction:	Serum
Platform:	GPL21572
Method:	Microarray
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	2546
Sample treatment protocol:	Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes.
RNA Extract protocol:	RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water.
RNA library preparation protocol:	Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.

Reference

PMID:	29348816
Title:	Development of a predictive miRNA signature for breast cancer risk among high-risk women.
Author:	Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME
Journal:	Oncotarget. 2017 Nov 28;8(68):112170-112183.
Description:	We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.