Entry Detail



General Information

Database ID:exR0356547
RNA Name:hsa-miR-206
RNA Type:miRNA
Chromosome:chr6
Starnd:+
Coordinate:
Start Site(bp):52144401End Site(bp):52144422
External Links:hsa-miR-206



Disease Information

Disease Name:Breast Cancer
Disease Category:Cancers
MeSH ID:D001943
Type:Neoplasms/Breast Neoplasms
Alias:Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast



Expression Detail

GEO ID:GSE98181
Description:Circulating miRNA profiles from serum of women at high-risk for breast cancer
Experimental Design:Cancer vs Control
Case Disease Type:Breast Cancer
Case Disease SubType:NA
Case Sample:Breast Cancer
Control Sample:Healthy
Number of Case:24
Number of Control:24
Number of Samples:48





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
CAPNS1
chr19
36139953
36150353
+
NPEPPS
chr17
47522942
47623276
+
SPRED1
chr15
38252836
38357249
+
SLC30A7
chr1
100896076
100981757
+
DDX5
chr17
64498254
64508199
-
TRIM2
chr4
153152342
153339317
+
DLG3
chrX
70444835
70505490
+
LASP1
chr17
38869859
38921770
+
RTL8B
chrX
135020513
135022542
-
FOXP1
chr3
70952817
71583993
-
SDCBP
chr8
58552924
58582859
+
NME1-NME2
chr17
51153590
51171744
+
NR2C2
chr3
14947584
15053600
+
TNRC6B
chr22
40044817
40335808
+
CREB3L2
chr7
137874979
138002086
-
NETO2
chr16
47077703
47143945
-
ZNF518A
chr10
96129715
96205288
+
PGM2
chr4
37826660
37862937
+
PRR12
chr19
49591182
49626439
+
PTBP1
chr19
797075
812327
+
CALM1
chr14
90396502
90408268
+
NME2
chr17
51165435
51171747
+
AP1S1
chr7
101154456
101161596
+
MAPK1
chr22
21754500
21867680
-
GID4
chr17
18039408
18068405
+
SMCO4
chr11
93478472
93543391
-
SS18
chr18
26016253
26091217
-
CWC15
chr11
94962620
94973586
-
WIPF2
chr17
40219304
40284136
+
WDR5
chr9
134135365
134159968
+
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000816
chr17
80521229
80526077
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC005332.7
chr17
68188547
68189165
+
AC145207.5
chr17
81878425
81881106
-
LINC00641
chr14
21200079
21206900
-
MALAT1
chr11
65497688
65506516
+
MIR4435-2HG
chr2
111006015
111523376
-
NEAT1
chr11
65422774
65445540
+
RMRP
chr9
35657751
35658018
-
Display:



Experiment Detail

GEO ID:GSE98181
Sample Source:Blood
Source Fraction:Serum
Platform:GPL21572
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2546
Sample treatment protocol:Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes.
RNA Extract protocol:RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water.
RNA library preparation protocol:Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.



Reference

PMID:29348816
Title:Development of a predictive miRNA signature for breast cancer risk among high-risk women.
Author:Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME
Journal:Oncotarget. 2017 Nov 28;8(68):112170-112183.
Description:We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.