Entry Detail



General Information

Database ID:exR0356581
RNA Name:hsa-miR-217-5p
RNA Type:miRNA
Chromosome:chr2
Starnd:-
Coordinate:
Start Site(bp):55983020End Site(bp):55983042
External Links:hsa-miR-217-5p



Disease Information

Disease Name:Breast Cancer
Disease Category:Cancers
MeSH ID:D001943
Type:Neoplasms/Breast Neoplasms
Alias:Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast



Expression Detail

GEO ID:GSE98181
Description:Circulating miRNA profiles from serum of women at high-risk for breast cancer
Experimental Design:Cancer vs Control
Case Disease Type:Breast Cancer
Case Disease SubType:NA
Case Sample:Breast Cancer
Control Sample:Healthy
Number of Case:24
Number of Control:24
Number of Samples:48





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
PNPO
chr17
47941506
47949308
+
SLC26A2
chr5
149960758
149993455
+
ICAM1
chr19
10271093
10286615
+
ARHGAP11A
chr15
32615144
32639941
+
SFXN1
chr5
175477062
175529742
+
EIF1AD
chr11
65996545
66002176
-
KPNA4
chr3
160495007
160565571
-
LYSMD4
chr15
99715697
99733561
-
AXL
chr19
41219223
41261766
+
OPA3
chr19
45527427
45602212
-
IRF4
chr6
391752
411443
+
SLC25A32
chr8
103398635
103415189
-
UBE2G1
chr17
4269259
4366628
-
MMD
chr17
55392622
55421924
-
CDH1
chr16
68737292
68835541
+
ICK
chr6
53001279
53061802
-
PARD6B
chr20
50731580
50756795
+
GOLGA3
chr12
132768914
132829078
-
MET
chr7
116672196
116798386
+
ACER2
chr9
19409009
19452505
+
PSKH1
chr16
67893254
67929676
+
EIF2S3
chrX
24054946
24078810
+
VHL
chr3
10141008
10152220
+
DDX3X
chrX
41333284
41364472
+
ZNF587
chr19
57849859
57865117
+
TSEN54
chr17
75516060
75524735
+
CNN2
chr19
1026586
1039068
+
CHD9
chr16
53055033
53329150
+
ERLIN1
chr10
100150094
100186033
-
TFPI
chr2
187464230
187565760
-
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
ADAMTSL4-AS1
chr1
150560202
150574552
-
AP000553.1
chr22
21652270
21670237
+
GAS5
chr1
173858559
173868882
-
LINC01578
chr15
92819540
92899701
+
MALAT1
chr11
65497688
65506516
+
NEAT1
chr11
65422774
65445540
+
OIP5-AS1
chr15
41283990
41309737
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE98181
Sample Source:Blood
Source Fraction:Serum
Platform:GPL21572
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2546
Sample treatment protocol:Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes.
RNA Extract protocol:RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water.
RNA library preparation protocol:Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.



Reference

PMID:29348816
Title:Development of a predictive miRNA signature for breast cancer risk among high-risk women.
Author:Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME
Journal:Oncotarget. 2017 Nov 28;8(68):112170-112183.
Description:We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.