exRNAdisease

General Information

Database ID:

exR0356592

RNA Name:

hsa-miR-221-3p

RNA Type:

miRNA

Chromosome:

chrX

Starnd:

Coordinate:

Start Site(bp):

45746180

End Site(bp):

45746202

External Links:

Disease Information

Disease Name:	Breast Cancer
Disease Category:	Cancers
MeSH ID:	D001943
Type:	Neoplasms/Breast Neoplasms
Alias:	Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast

Expression Detail

GEO ID:	GSE98181
Description:	Circulating miRNA profiles from serum of women at high-risk for breast cancer
Experimental Design:	Cancer vs Control
Case Disease Type:	Breast Cancer
Case Disease SubType:	NA
Case Sample:	Breast Cancer
Control Sample:	Healthy
Number of Case:	24
Number of Control:	24
Number of Samples:	48

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
ACVR2B	chr3	38453890	38493142	+
AP3M1	chr10	74120255	74151063	-
DNAJC14	chr12	55820960	55830824	-
EFNA1	chr1	155127876	155134899	+
KDSR	chr18	63327726	63367228	-
MPZL1	chr1	167721192	167791919	+
PPIL1	chr6	36854827	36874803	-
TBL1X	chrX	9463295	9741037	+
TUB	chr11	8019244	8106112	+
ZBTB5	chr9	37438102	37465450	-
DDIT4	chr10	72273924	72276036	+
FUS	chr16	31180110	31194871	+
MAPRE1	chr20	32819954	32850405	+
RIPOR2	chr6	24804282	25042170	-
SP4	chr7	21428043	21514822	+
TUBA1B	chr12	49127782	49131397	-
ZNF649	chr19	51889235	51905040	-

miRNA targets:

circRNA targets:

circRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa_circ_0001247	chr22	46125304	46136418	+
hsa_circ_0000670	chr16	9199043	9199243	+

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC020978.7	chr16	68224713	68227734	+
AC022150.4	chr19	52650437	52653284	-
ARHGAP27P1-BPTFP1-KPNA2P3	chr17	64749663	64781707	-
GAS5	chr1	173858559	173868882	-
NEAT1	chr11	65422774	65445540	+
TUG1	chr22	30969245	30979395	+
TYMSOS	chr18	630886	658340	-

Display:

Experiment Detail

GEO ID:	GSE98181
Sample Source:	Blood
Source Fraction:	Serum
Platform:	GPL21572
Method:	Microarray
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	2546
Sample treatment protocol:	Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes.
RNA Extract protocol:	RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water.
RNA library preparation protocol:	Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.

Reference

PMID:	29348816
Title:	Development of a predictive miRNA signature for breast cancer risk among high-risk women.
Author:	Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME
Journal:	Oncotarget. 2017 Nov 28;8(68):112170-112183.
Description:	We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.