Entry Detail



General Information

Database ID:exR0356608
RNA Name:hsa-miR-23a-3p
RNA Type:miRNA
Chromosome:chr19
Starnd:-
Coordinate:
Start Site(bp):13836595End Site(bp):13836615
External Links:hsa-miR-23a-3p



Disease Information

Disease Name:Breast Cancer
Disease Category:Cancers
MeSH ID:D001943
Type:Neoplasms/Breast Neoplasms
Alias:Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast



Expression Detail

GEO ID:GSE98181
Description:Circulating miRNA profiles from serum of women at high-risk for breast cancer
Experimental Design:Cancer vs Control
Case Disease Type:Breast Cancer
Case Disease SubType:NA
Case Sample:Breast Cancer
Control Sample:Healthy
Number of Case:24
Number of Control:24
Number of Samples:48





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ADGRG6
chr6
142301854
142446266
+
ATAD1
chr10
87751512
87841343
-
ATXN7L3
chr17
44191805
44200113
-
FKBP5
chr6
35573585
35728583
-
GATAD2B
chr1
153789030
153923360
-
IRF4
chr6
391752
411443
+
KLF12
chr13
73686089
73995056
-
PHLDA1
chr12
76025447
76033932
-
TK2
chr16
66508003
66552544
-
TNFAIP3
chr6
137867214
137883312
+
TOB2
chr22
41433494
41446801
-
USP54
chr10
73497538
73625953
-
VAT1
chr17
43014607
43025123
-
AC008758.1
chr19
12461559
12551474
-
ATP5MD
chr10
103389041
103396492
-
BACE2
chr21
41167801
41282530
+
GSTP1
chr11
67583742
67586656
+
ZNF709
chr19
12461184
12513854
-
ZNF91
chr19
23304991
23395471
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000384
chr12
27867712
27877119
+
hsa_circ_0000711
chr16
68155889
68160513
+
hsa_circ_0000881
chr19
5653125
5654467
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC007780.1
chr17
68413623
68524949
+
AC011503.2
chr19
23927788
23929287
+
AC078846.1
chr7
129604548
129611630
-
AC091564.7
chr11
6610883
6616594
-
AC124068.2
chr15
89335053
89336161
+
AC144548.1
chr12
110387463
110445548
-
AL035458.2
chr20
34234840
34281173
-
GAS5
chr1
173858559
173868882
-
MALAT1
chr11
65497688
65506516
+
MCM3AP-AS1
chr21
46229196
46259390
+
NEAT1
chr11
65422774
65445540
+
SNHG16
chr17
76557764
76565348
+
SNHG5
chr6
85650491
85678932
-
STAG3L5P-PVRIG2P-PILRB
chr7
100336104
100367831
+
TYMSOS
chr18
630886
658340
-
XIST
chrX
73820649
73852723
-
Z93241.1
chr22
42615244
42615907
+
ZNF674-AS1
chrX
46545438
46548841
+
Display:



Experiment Detail

GEO ID:GSE98181
Sample Source:Blood
Source Fraction:Serum
Platform:GPL21572
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2546
Sample treatment protocol:Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes.
RNA Extract protocol:RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water.
RNA library preparation protocol:Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.



Reference

PMID:29348816
Title:Development of a predictive miRNA signature for breast cancer risk among high-risk women.
Author:Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME
Journal:Oncotarget. 2017 Nov 28;8(68):112170-112183.
Description:We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.