exRNAdisease

General Information

Database ID:

exR0356647

RNA Name:

hsa-miR-29b-3p

RNA Type:

miRNA

Chromosome:

chr7

Starnd:

Coordinate:

Start Site(bp):

130877467

End Site(bp):

130877489

External Links:

Disease Information

Disease Name:	Breast Cancer
Disease Category:	Cancers
MeSH ID:	D001943
Type:	Neoplasms/Breast Neoplasms
Alias:	Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast

Expression Detail

GEO ID:	GSE98181
Description:	Circulating miRNA profiles from serum of women at high-risk for breast cancer
Experimental Design:	Cancer vs Control
Case Disease Type:	Breast Cancer
Case Disease SubType:	NA
Case Sample:	Breast Cancer
Control Sample:	Healthy
Number of Case:	24
Number of Control:	24
Number of Samples:	48

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AMER1	chrX	64185117	64205708	-
APH1A	chr1	150265399	150269580	-
APP	chr21	25880550	26171128	-
BACH2	chr6	89926528	90296908	-
BIRC5	chr17	78214186	78225636	+
C1QTNF6	chr22	37180166	37199385	-
CALU	chr7	128739292	128773400	+
CREG1	chr1	167529117	167553805	-
FASN	chr17	82078338	82098294	-
KLHL28	chr14	44924319	45042322	-
KMT5C	chr19	55339853	55348121	+
MDN1	chr6	89642498	89819794	-
NASP	chr1	45583846	45618904	+
NMI	chr2	151270470	151289894	-
PER3	chr1	7784320	7845177	+
PGK1	chrX	77910739	78129295	+
QKI	chr6	163414000	163578592	+
RNF138	chr18	32091874	32131561	+
SH3GLB1	chr1	86704570	86748184	+

miRNA targets:

circRNA targets:

circRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa_circ_0000018	chr1	15860731	15863309	+

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC007036.3	chr7	30157531	30159534	+
AC012146.1	chr17	5111468	5115004	+
AC018521.1	chr17	47945424	47981736	+
AL137129.1	chr14	61734138	61776260	+
AL355488.1	chr1	110370154	110373003	+
AL391244.1	chr1	1420245	1422691	+
AP001432.1	chr21	37221419	37237744	+
H19	chr11	1995176	2001470	-
MIR4458HG	chr5	8450701	8486930	+
MIR497HG	chr17	7015818	7019659	-
MIRLET7BHG	chr22	46053869	46113928	+
NEAT1	chr11	65422774	65445540	+
OIP5-AS1	chr15	41283990	41309737	+
TUG1	chr22	30969245	30979395	+
XIST	chrX	73820649	73852723	-

Display:

Experiment Detail

GEO ID:	GSE98181
Sample Source:	Blood
Source Fraction:	Serum
Platform:	GPL21572
Method:	Microarray
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	2546
Sample treatment protocol:	Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes.
RNA Extract protocol:	RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water.
RNA library preparation protocol:	Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.

Reference

PMID:	29348816
Title:	Development of a predictive miRNA signature for breast cancer risk among high-risk women.
Author:	Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME
Journal:	Oncotarget. 2017 Nov 28;8(68):112170-112183.
Description:	We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.