Entry Detail



General Information

Database ID:exR0356654
RNA Name:hsa-miR-302a-3p
RNA Type:miRNA
Chromosome:chr4
Starnd:-
Coordinate:
Start Site(bp):112648186End Site(bp):112648208
External Links:hsa-miR-302a-3p



Disease Information

Disease Name:Breast Cancer
Disease Category:Cancers
MeSH ID:D001943
Type:Neoplasms/Breast Neoplasms
Alias:Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast



Expression Detail

GEO ID:GSE98181
Description:Circulating miRNA profiles from serum of women at high-risk for breast cancer
Experimental Design:Cancer vs Control
Case Disease Type:Breast Cancer
Case Disease SubType:NA
Case Sample:Breast Cancer
Control Sample:Healthy
Number of Case:24
Number of Control:24
Number of Samples:48





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ZBTB5
chr9
37438102
37465450
-
PPP1R8
chr1
27830782
27851676
+
ATP6V1C1
chr8
103021063
103073051
+
SEC23B
chr20
18507520
18561415
+
FABP5
chr8
81280536
81284777
+
THRAP3
chr1
36224432
36305357
+
LONP2
chr16
48244300
48363122
+
KLC1
chr14
103561896
103714249
+
FAM222B
chr17
28755978
28855232
-
WASF3
chr13
26557683
26688948
+
TOP2A
chr17
40388525
40417896
-
APP
chr21
25880550
26171128
-
ARL4A
chr7
12686856
12690958
+
PDRG1
chr20
31944337
31952046
-
SCAMP2
chr15
74843730
74873365
-
RAB31
chr18
9708275
9862551
+
IKZF4
chr12
56007659
56038435
+
RACGAP1
chr12
49976923
50033136
-
MGLL
chr3
127689062
128052190
-
HABP4
chr9
96450169
96491336
+
USP6NL
chr10
11453946
11611754
-
RGMA
chr15
93035273
93089204
-
JARID2
chr6
15246069
15522042
+
BAZ1B
chr7
73440406
73522293
-
CLIP4
chr2
29097705
29189643
+
IPO7
chr11
9384652
9448127
+
SEC23IP
chr10
119892730
119944657
+
VLDLR
chr9
2621787
2660056
+
IZUMO2
chr19
50152548
50163195
-
SSR1
chr6
7268306
7347446
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000943
chr19
47421744
47440665
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC011503.2
chr19
23927788
23929287
+
AC125257.1
chr17
41848518
41851447
-
AL049840.4
chr14
103694516
103695050
-
ARHGAP27P1-BPTFP1-KPNA2P3
chr17
64749663
64781707
-
FGD5-AS1
chr3
14920347
14948424
-
MIR17HG
chr13
91347820
91354579
+
NEAT1
chr11
65422774
65445540
+
NORAD
chr20
36045618
36051018
-
SNHG16
chr17
76557764
76565348
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE98181
Sample Source:Blood
Source Fraction:Serum
Platform:GPL21572
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2546
Sample treatment protocol:Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes.
RNA Extract protocol:RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water.
RNA library preparation protocol:Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.



Reference

PMID:29348816
Title:Development of a predictive miRNA signature for breast cancer risk among high-risk women.
Author:Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME
Journal:Oncotarget. 2017 Nov 28;8(68):112170-112183.
Description:We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.