Entry Detail



General Information

Database ID:exR0356656
RNA Name:hsa-miR-302b-3p
RNA Type:miRNA
Chromosome:chr4
Starnd:-
Coordinate:
Start Site(bp):112648489End Site(bp):112648511
External Links:hsa-miR-302b-3p



Disease Information

Disease Name:Breast Cancer
Disease Category:Cancers
MeSH ID:D001943
Type:Neoplasms/Breast Neoplasms
Alias:Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast



Expression Detail

GEO ID:GSE98181
Description:Circulating miRNA profiles from serum of women at high-risk for breast cancer
Experimental Design:Cancer vs Control
Case Disease Type:Breast Cancer
Case Disease SubType:NA
Case Sample:Breast Cancer
Control Sample:Healthy
Number of Case:24
Number of Control:24
Number of Samples:48





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
RPP14
chr3
58306247
58324695
+
SWSAP1
chr19
11374666
11376951
+
GPBP1
chr5
57173948
57264679
+
C18orf21
chr18
35972625
35979286
+
PXYLP1
chr3
141228726
141367753
+
ALG5
chr13
36949738
37000261
-
SERINC1
chr6
122443351
122471807
-
RGMA
chr15
93035273
93089204
-
CLCN6
chr1
11806096
11848079
+
KCTD10
chr12
109448655
109477359
-
PLS3
chrX
115561174
115650861
+
RPLP1
chr15
69452814
69456205
+
DNAJB6
chr7
157335381
157417439
+
SYAP1
chrX
16719612
16765340
+
RNF149
chr2
101271219
101308701
-
SLC35G1
chr10
93893973
93956062
+
MSL1
chr17
40121971
40136917
+
SND1
chr7
127652194
128092609
+
WASF3
chr13
26557683
26688948
+
CTR9
chr11
10751246
10801625
+
HMGCS1
chr5
43287470
43313512
-
CDK6
chr7
92604921
92836594
-
WDR37
chr10
1049538
1132384
+
ATP6V1B2
chr8
20197381
20226819
+
CTSC
chr11
88293592
88337761
-
HSPA9
chr5
138553756
138575416
-
ZNF281
chr1
200404940
200410056
-
CELF2
chr10
10798397
11336675
+
TNRC6A
chr16
24610209
24827632
+
ATP13A2
chr1
16985958
17011928
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000943
chr19
47421744
47440665
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC011503.2
chr19
23927788
23929287
+
AC021078.1
chr5
149494314
149504670
-
AC125257.1
chr17
41848518
41851447
-
AL049840.4
chr14
103694516
103695050
-
ARHGAP27P1-BPTFP1-KPNA2P3
chr17
64749663
64781707
-
FGD5-AS1
chr3
14920347
14948424
-
MIR17HG
chr13
91347820
91354579
+
NEAT1
chr11
65422774
65445540
+
NORAD
chr20
36045618
36051018
-
SNHG16
chr17
76557764
76565348
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE98181
Sample Source:Blood
Source Fraction:Serum
Platform:GPL21572
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2546
Sample treatment protocol:Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes.
RNA Extract protocol:RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water.
RNA library preparation protocol:Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.



Reference

PMID:29348816
Title:Development of a predictive miRNA signature for breast cancer risk among high-risk women.
Author:Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME
Journal:Oncotarget. 2017 Nov 28;8(68):112170-112183.
Description:We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.