Entry Detail



General Information

Database ID:exR0356658
RNA Name:hsa-miR-302c-3p
RNA Type:miRNA
Chromosome:chr4
Starnd:-
Coordinate:
Start Site(bp):112648366End Site(bp):112648388
External Links:hsa-miR-302c-3p



Disease Information

Disease Name:Breast Cancer
Disease Category:Cancers
MeSH ID:D001943
Type:Neoplasms/Breast Neoplasms
Alias:Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast



Expression Detail

GEO ID:GSE98181
Description:Circulating miRNA profiles from serum of women at high-risk for breast cancer
Experimental Design:Cancer vs Control
Case Disease Type:Breast Cancer
Case Disease SubType:NA
Case Sample:Breast Cancer
Control Sample:Healthy
Number of Case:24
Number of Control:24
Number of Samples:48





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
MTMR12
chr5
32226994
32312987
-
TXNIP
chr1
145992435
145996579
-
CLU
chr8
27596917
27614700
-
MBP
chr18
76978827
77133683
-
CCNB1
chr5
69167135
69178245
+
SETD7
chr4
139495941
139606699
-
NUP153
chr6
17615035
17706834
-
SEC16A
chr9
136440096
136483759
-
SLAIN2
chr4
48341529
48426201
+
ZSCAN26
chr6
28267010
28278224
+
CUL1
chr7
148697914
148801110
+
TRA2A
chr7
23504780
23532041
-
TEFM
chr17
30897336
30906238
-
CCNG2
chr4
77157207
77433388
+
CDK6
chr7
92604921
92836594
-
FYCO1
chr3
45917899
45995824
-
PSMD5
chr9
120815496
120842951
-
MTFR2
chr6
136231024
136250335
-
VRK1
chr14
96797382
96931722
+
UGP2
chr2
63840940
63891562
+
KMT5B
chr11
68154863
68213828
-
SEMA3C
chr7
80742538
80922359
-
COX7C
chr5
86617928
86620962
+
SRRT
chr7
100875103
100888664
+
BCL7A
chr12
122019422
122062044
+
PDXK
chr21
43719094
43762307
+
MOB1A
chr2
74152528
74178898
-
MSTO1
chr1
155610188
155614971
+
NPC2
chr14
74476192
74494177
-
CAMK2N1
chr1
20482391
20486210
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000943
chr19
47421744
47440665
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC011503.2
chr19
23927788
23929287
+
AC125257.1
chr17
41848518
41851447
-
AL049840.4
chr14
103694516
103695050
-
ARHGAP27P1-BPTFP1-KPNA2P3
chr17
64749663
64781707
-
FGD5-AS1
chr3
14920347
14948424
-
MIR17HG
chr13
91347820
91354579
+
NEAT1
chr11
65422774
65445540
+
NORAD
chr20
36045618
36051018
-
SNHG16
chr17
76557764
76565348
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE98181
Sample Source:Blood
Source Fraction:Serum
Platform:GPL21572
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2546
Sample treatment protocol:Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes.
RNA Extract protocol:RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water.
RNA library preparation protocol:Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.



Reference

PMID:29348816
Title:Development of a predictive miRNA signature for breast cancer risk among high-risk women.
Author:Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME
Journal:Oncotarget. 2017 Nov 28;8(68):112170-112183.
Description:We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.