Entry Detail



General Information

Database ID:exR0356827
RNA Name:hsa-miR-330-5p
RNA Type:miRNA
Chromosome:chr19
Starnd:-
Coordinate:
Start Site(bp):45639049End Site(bp):45639070
External Links:hsa-miR-330-5p



Disease Information

Disease Name:Breast Cancer
Disease Category:Cancers
MeSH ID:D001943
Type:Neoplasms/Breast Neoplasms
Alias:Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast



Expression Detail

GEO ID:GSE98181
Description:Circulating miRNA profiles from serum of women at high-risk for breast cancer
Experimental Design:Cancer vs Control
Case Disease Type:Breast Cancer
Case Disease SubType:NA
Case Sample:Breast Cancer
Control Sample:Healthy
Number of Case:24
Number of Control:24
Number of Samples:48





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ZNF3
chr7
100064033
100082548
-
ALDH5A1
chr6
24494867
24537207
+
ENG
chr9
127815012
127854756
-
NEMP1
chr12
57055643
57088063
-
STX3
chr11
59713456
59805882
+
RTL10
chr22
19846138
19854896
-
GIPC1
chr19
14477760
14496149
-
ANKRD13B
chr17
29589769
29614761
+
UBE4A
chr11
118359585
118399211
+
MARK2
chr11
63838928
63911019
+
ATXN1
chr6
16299112
16761491
-
NME4
chr16
396725
410367
+
TMEM127
chr2
96248516
96265994
-
PDXK
chr21
43719094
43762307
+
GUCD1
chr22
24540423
24555935
-
MTG2
chr20
62183029
62203568
+
VLDLR
chr9
2621787
2660056
+
EIF4A1
chr17
7572706
7579006
+
GIGYF1
chr7
100679507
100694037
-
DOLPP1
chr9
129081111
129090438
+
SMAD3
chr15
67063763
67195169
+
MAP4
chr3
47850690
48089272
-
ABL1
chr9
130713016
130887675
+
PAQR4
chr16
2969270
2973484
+
NR4A2
chr2
156324437
156342348
-
CRTC3
chr15
90529923
90645345
+
PPME1
chr11
74171267
74254703
+
GOSR2
chr17
46923075
46975524
+
MYO1C
chr17
1464186
1492686
-
AGTRAP
chr1
11736084
11754802
+
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000128
chr1
151139409
151139890
+
hsa_circ_0000384
chr12
27867712
27877119
+
hsa_circ_0001727
chr7
99621041
99621930
+
hsa_circ_0001865
chr9
86292641
86293514
-
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC016876.2
chr17
7581964
7584086
-
AC144548.1
chr12
110387463
110445548
-
AL355075.4
chr14
20343048
20343685
-
AL359924.1
chr1
237862175
237928321
+
AP000553.1
chr22
21652270
21670237
+
KCNQ1OT1
chr11
2608328
2699994
-
MIRLET7BHG
chr22
46053869
46113928
+
NEAT1
chr11
65422774
65445540
+
SNHG1
chr11
62851984
62855953
-
SNHG3
chr1
28505980
28510892
+
TUG1
chr22
30969245
30979395
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE98181
Sample Source:Blood
Source Fraction:Serum
Platform:GPL21572
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2546
Sample treatment protocol:Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes.
RNA Extract protocol:RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water.
RNA library preparation protocol:Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.



Reference

PMID:29348816
Title:Development of a predictive miRNA signature for breast cancer risk among high-risk women.
Author:Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME
Journal:Oncotarget. 2017 Nov 28;8(68):112170-112183.
Description:We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.