exRNAdisease

General Information

Database ID:

exR0356834

RNA Name:

hsa-miR-338-3p

RNA Type:

miRNA

Chromosome:

chr17

Starnd:

Coordinate:

Start Site(bp):

81125887

End Site(bp):

81125908

External Links:

Disease Information

Disease Name:	Breast Cancer
Disease Category:	Cancers
MeSH ID:	D001943
Type:	Neoplasms/Breast Neoplasms
Alias:	Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast

Expression Detail

GEO ID:	GSE98181
Description:	Circulating miRNA profiles from serum of women at high-risk for breast cancer
Experimental Design:	Cancer vs Control
Case Disease Type:	Breast Cancer
Case Disease SubType:	NA
Case Sample:	Breast Cancer
Control Sample:	Healthy
Number of Case:	24
Number of Control:	24
Number of Samples:	48

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
ADCY9	chr16	3953387	4116442	-
ARPC1B	chr7	99374249	99394816	+
CALU	chr7	128739292	128773400	+
CDT1	chr16	88803789	88809258	+
ENSA	chr1	150600851	150629612	-
ERG28	chr14	75649791	75660876	-
GTSE1	chr22	46296870	46330810	+
KDSR	chr18	63327726	63367228	-
NONO	chrX	71283192	71301168	+
PALLD	chr4	168497052	168928457	+
PURB	chr7	44876299	44885530	-
RAB14	chr9	121178133	121223014	-
TANC2	chr17	63009556	63427699	+
TRIM33	chr1	114392790	114511203	-

miRNA targets:

circRNA targets:

circRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa_circ_0001025	chr2	69565029	69565697	-
hsa_circ_0000284	chr11	33307958	33309057	+
hsa_circ_0001085	chr2	191765289	191789319	+

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC008738.7	chr19	33207129	33207639	+
AC109460.3	chr16	28974804	28990775	+
KCNQ1OT1	chr11	2608328	2699994	-
LINC00943	chr12	126723412	126749027	+
MALAT1	chr11	65497688	65506516	+
NEAT1	chr11	65422774	65445540	+
OIP5-AS1	chr15	41283990	41309737	+
SDCBP2-AS1	chr20	1325405	1378735	+
XIST	chrX	73820649	73852723	-

Display:

Experiment Detail

GEO ID:	GSE98181
Sample Source:	Blood
Source Fraction:	Serum
Platform:	GPL21572
Method:	Microarray
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	2546
Sample treatment protocol:	Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes.
RNA Extract protocol:	RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water.
RNA library preparation protocol:	Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.

Reference

PMID:	29348816
Title:	Development of a predictive miRNA signature for breast cancer risk among high-risk women.
Author:	Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME
Journal:	Oncotarget. 2017 Nov 28;8(68):112170-112183.
Description:	We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.