Entry Detail



General Information

Database ID:exR0356841
RNA Name:hsa-miR-33b-5p
RNA Type:miRNA
Chromosome:chr17
Starnd:-
Coordinate:
Start Site(bp):17813897End Site(bp):17813916
External Links:hsa-miR-33b-5p



Disease Information

Disease Name:Breast Cancer
Disease Category:Cancers
MeSH ID:D001943
Type:Neoplasms/Breast Neoplasms
Alias:Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast



Expression Detail

GEO ID:GSE98181
Description:Circulating miRNA profiles from serum of women at high-risk for breast cancer
Experimental Design:Cancer vs Control
Case Disease Type:Breast Cancer
Case Disease SubType:NA
Case Sample:Breast Cancer
Control Sample:Healthy
Number of Case:24
Number of Control:24
Number of Samples:48





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ADCY9
chr16
3953387
4116442
-
AFF4
chr5
132875395
132963634
-
BTBD7
chr14
93237550
93333092
-
CERK
chr22
46684410
46738252
-
CROT
chr7
87345681
87399795
+
DDX5
chr17
64498254
64508199
-
E2F3
chr6
20401879
20493714
+
ECHDC1
chr6
127288712
127343609
-
EIF5A2
chr3
170888418
170908644
-
IGF1R
chr15
98648539
98964530
+
IRS2
chr13
109752695
109786583
-
MAPK1IP1L
chr14
55051647
55070194
+
MAPK6
chr15
51952106
52067375
+
MTHFD2
chr2
74198610
74217565
+
MYO19
chr17
36495633
36543435
-
NAA15
chr4
139301505
139420033
+
NFAT5
chr16
69565094
69704666
+
PIM1
chr6
37170152
37175428
+
RBM33
chr7
155644451
155781485
+
RCAN1
chr21
34513142
34615113
-
ROBO1
chr3
78597239
79767998
-
SLC39A8
chr4
102251041
102431258
-
SULF2
chr20
47656348
47786616
-
TNPO1
chr5
72816312
72916733
+
TPM1
chr15
63042632
63071915
+
UBN2
chr7
139230356
139308236
+
WDFY3
chr4
84669610
84966391
-
XRN1
chr3
142306607
142448062
-
ZFYVE16
chr5
80408013
80483379
+
ZNF148
chr3
125225561
125375354
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000540
chr14
55799534
55821940
+
hsa_circ_0001349
chr3
152132729
152150709
+
hsa_circ_0000642
chr15
80390757
80415142
+
hsa_circ_0000643
chr15
80412669
80415142
+
hsa_circ_0000284
chr11
33307958
33309057
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC023509.1
chr12
53441741
53467528
+
DANCR
chr4
52712404
52720351
+
FGD5-AS1
chr3
14920347
14948424
-
MCF2L-AS1
chr13
112967484
112968824
-
NEAT1
chr11
65422774
65445540
+
Display:



Experiment Detail

GEO ID:GSE98181
Sample Source:Blood
Source Fraction:Serum
Platform:GPL21572
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2546
Sample treatment protocol:Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes.
RNA Extract protocol:RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water.
RNA library preparation protocol:Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.



Reference

PMID:29348816
Title:Development of a predictive miRNA signature for breast cancer risk among high-risk women.
Author:Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME
Journal:Oncotarget. 2017 Nov 28;8(68):112170-112183.
Description:We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.