exRNAdisease

Entry Detail

---



General Information

Database ID: exR0356879 RNA Name: hsa-miR-362-3p RNA Type: miRNA Chromosome: chrX Starnd: + Coordinate: Start Site(bp): 50009005 End Site(bp): 50009026 External Links: hsa-miR-362-3p

Disease Information

Disease Name: Breast Cancer Disease Category: Cancers MeSH ID: D001943 Type: Neoplasms/Breast Neoplasms Alias: Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast

Expression Detail

GEO ID: GSE98181 Description: Circulating miRNA profiles from serum of women at high-risk for breast cancer Experimental Design: Cancer vs Control Case Disease Type: Breast Cancer Case Disease SubType: NA Case Sample: Breast Cancer Control Sample: Healthy Number of Case: 24 Number of Control: 24 Number of Samples: 48

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand PTPRJ chr11 47980558 48170841 + KIAA0232 chr4 6781375 6884170 + USF2 chr19 35268962 35279821 + BLCAP chr20 37492472 37527931 - AC009133.6 chr16 29812261 29820092 + WDR82 chr3 52254434 52288020 - PIP4K2B chr17 38765689 38800126 - ARF3 chr12 48935723 48957487 - TRPS1 chr8 115408496 115809673 - UBTF chr17 44205033 44221626 - FAM126B chr2 200973718 201071671 - ZBTB2 chr6 151364115 151391559 - TNFRSF21 chr6 47231532 47309905 - RUNX1 chr21 34787801 36004667 - MTPN chr7 135926760 135977359 - SERTAD3 chr19 40440844 40444335 - DCBLD2 chr3 98795941 98901695 - ATP8B1 chr18 57646426 57803315 - SLF2 chr10 100912963 100965134 + SDCBP chr8 58552924 58582859 + TNFRSF1B chr1 12166991 12209228 + COQ8A chr1 226897536 226987545 + DNAJB9 chr7 108569867 108574850 + VAMP2 chr17 8159149 8163546 - SIK1B chr21 6111131 6123778 + SMAP2 chr1 40344850 40423326 + FAM219A chr9 34398184 34458570 - CA12 chr15 63321378 63381846 - CALM1 chr14 90396502 90408268 + AKAP11 chr13 42272152 42323261 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001588 chr6 26204839 26205043 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC016876.2 chr17 7581964 7584086 - KCNQ1OT1 chr11 2608328 2699994 - MIR663AHG chr20 26167817 26251546 - NEAT1 chr11 65422774 65445540 + SCARNA9 chr11 93721513 93721865 + SNHG25 chr17 64145970 64146476 + STAG3L5P-PVRIG2P-PILRB chr7 100336104 100367831 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE98181 Sample Source: Blood Source Fraction: Serum Platform: GPL21572 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2546 Sample treatment protocol: Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes. RNA Extract protocol: RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water. RNA library preparation protocol: Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.

Reference

PMID: 29348816 Title: Development of a predictive miRNA signature for breast cancer risk among high-risk women. Author: Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME Journal: Oncotarget. 2017 Nov 28;8(68):112170-112183. Description: We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.