exRNAdisease

Entry Detail

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General Information

Database ID: exR0356891 RNA Name: hsa-miR-3648 RNA Type: miRNA Chromosome: chr21 Starnd: + Coordinate: Start Site(bp): 8987026 End Site(bp): 8987046 External Links: hsa-miR-3648

Disease Information

Disease Name: Breast Cancer Disease Category: Cancers MeSH ID: D001943 Type: Neoplasms/Breast Neoplasms Alias: Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast

Expression Detail

GEO ID: GSE98181 Description: Circulating miRNA profiles from serum of women at high-risk for breast cancer Experimental Design: Cancer vs Control Case Disease Type: Breast Cancer Case Disease SubType: NA Case Sample: Breast Cancer Control Sample: Healthy Number of Case: 24 Number of Control: 24 Number of Samples: 48

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand MT-CO2 chrMT 7586 8269 + THAP7 chr22 20999104 21002196 - CERS4 chr19 8206736 8262421 + ARL8B chr3 5122245 5180912 + EEF1G chr11 62559596 62574086 - FNBP4 chr11 47716494 47767443 - PTGES3 chr12 56663341 56688408 - AP002990.1 chr11 62559603 62591531 - PTCH2 chr1 44819844 44843253 - MAPK9 chr5 180233143 180292099 - ACTG1 chr17 81509971 81523847 - ECPAS chr9 111360692 111484745 - RNF126 chr19 647526 663233 - SF3A2 chr19 2236824 2248655 + TPT1 chr13 45333471 45341370 - AKIRIN2 chr6 87674860 87702233 - LZTS3 chr20 3162617 3173592 - AL133352.1 chr10 100505628 100529881 - ATP6V0A2 chr12 123712353 123761755 + SET chr9 128683424 128696400 + SH3GLB2 chr9 129007036 129028303 - PAM16 chr16 4331549 4355607 - LRRC45 chr17 82023305 82031151 + SRRM2 chr16 2752626 2772538 + NDUFB8 chr10 100523740 100530000 - GAPDH chr12 6534512 6538374 + CORO7-PAM16 chr16 4340251 4420494 - SKI chr1 2228319 2310213 + SSR2 chr1 156009048 156020951 - ARRDC4 chr15 97960703 97973833 + miRNA targets: NA circRNA targets: NA lncRNA targets: NA Display:

Experiment Detail

GEO ID: GSE98181 Sample Source: Blood Source Fraction: Serum Platform: GPL21572 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2546 Sample treatment protocol: Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes. RNA Extract protocol: RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water. RNA library preparation protocol: Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.

Reference

PMID: 29348816 Title: Development of a predictive miRNA signature for breast cancer risk among high-risk women. Author: Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME Journal: Oncotarget. 2017 Nov 28;8(68):112170-112183. Description: We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.