exRNAdisease

Entry Detail

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General Information

Database ID: exR0356895 RNA Name: hsa-miR-3652 RNA Type: miRNA Chromosome: chr12 Starnd: + Coordinate: Start Site(bp): 103930425 End Site(bp): 103930442 External Links: hsa-miR-3652

Disease Information

Disease Name: Breast Cancer Disease Category: Cancers MeSH ID: D001943 Type: Neoplasms/Breast Neoplasms Alias: Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast

Expression Detail

GEO ID: GSE98181 Description: Circulating miRNA profiles from serum of women at high-risk for breast cancer Experimental Design: Cancer vs Control Case Disease Type: Breast Cancer Case Disease SubType: NA Case Sample: Breast Cancer Control Sample: Healthy Number of Case: 24 Number of Control: 24 Number of Samples: 48

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ATP5MC3 chr2 175176258 175184607 - GANAB chr11 62624826 62646726 - HDLBP chr2 241227264 241317061 - PGRMC1 chrX 119236245 119244466 + PTMA chr2 231706895 231713541 + RAB15 chr14 64945814 64973226 - AC099811.2 chr17 42119674 42154916 - AP2A1 chr19 49766968 49807113 + AP2M1 chr3 184174689 184184091 + ARHGAP33 chr19 35774532 35788822 + BDNF chr11 27654893 27722058 - BRI3 chr7 98252379 98310441 + CCT6A chr7 56051685 56063989 + FKBP8 chr19 18531751 18544077 - GATC chr12 120446444 120463749 + GDF11 chr12 55743122 55757264 + HLA-DRA chr6 32439878 32445046 + HSP90B1 chr12 103930107 103953645 + MIB2 chr1 1615415 1630610 + RAB5C chr17 42124976 42155044 - SF3A2 chr19 2236824 2248655 + SFPQ chr1 35176378 35193145 - WASF1 chr6 110099819 110180004 - WBP11 chr12 14784582 14803486 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC022819.1 chr15 99157231 99161140 - AL591742.2 chr1 114032393 114034511 + Display:

Experiment Detail

GEO ID: GSE98181 Sample Source: Blood Source Fraction: Serum Platform: GPL21572 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2546 Sample treatment protocol: Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes. RNA Extract protocol: RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water. RNA library preparation protocol: Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.

Reference

PMID: 29348816 Title: Development of a predictive miRNA signature for breast cancer risk among high-risk women. Author: Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME Journal: Oncotarget. 2017 Nov 28;8(68):112170-112183. Description: We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.