exRNAdisease

Entry Detail

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General Information

Database ID: exR0356896 RNA Name: hsa-miR-3654 RNA Type: miRNA Chromosome: chr7 Starnd: - Coordinate: Start Site(bp): 133034860 End Site(bp): 133034878 External Links: hsa-miR-3654

Disease Information

Disease Name: Breast Cancer Disease Category: Cancers MeSH ID: D001943 Type: Neoplasms/Breast Neoplasms Alias: Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast

Expression Detail

GEO ID: GSE98181 Description: Circulating miRNA profiles from serum of women at high-risk for breast cancer Experimental Design: Cancer vs Control Case Disease Type: Breast Cancer Case Disease SubType: NA Case Sample: Breast Cancer Control Sample: Healthy Number of Case: 24 Number of Control: 24 Number of Samples: 48

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand TUBB chr6 30720352 30725426 + DEPDC1B chr5 60596912 60700190 - ERI2 chr16 20780193 20900349 - CCT7 chr2 73233420 73253021 + APLP2 chr11 130068147 130144811 + MRPL11 chr11 66435075 66466738 - HSPA8 chr11 123057489 123063230 - GGH chr8 63015079 63038806 - MDK chr11 46380756 46383837 + EGR1 chr5 138465479 138469303 + MKRN1 chr7 140453033 140479536 - RPS14 chr5 150442635 150449739 - DDTL chr22 23966888 23972556 + DCAF8 chr1 160215715 160262549 - RNPS1 chr16 2253116 2268397 - DCPS chr11 126304060 126350005 + MPRIP chr17 17042545 17217679 + RPL12 chr9 127447674 127451406 - RPL13A chr19 49487554 49492308 + RPS12 chr6 132814569 132817564 + HLA-DRA chr6 32439878 32445046 + STMN1 chr1 25884181 25906991 - RPS3 chr11 75399515 75422280 + RPL3 chr22 39312882 39320389 - FTH1 chr11 61959718 61967634 - TSPAN18 chr11 44726465 44932423 + HLA-DRB5 chr6 32517353 32530287 - NOLC1 chr10 102152176 102163871 + HMGA1 chr6 34236873 34246231 + CCDC85C chr14 99500190 99604207 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AD000090.1 chr19 35557956 35581954 + BCDIN3D-AS1 chr12 49827913 49841143 + LINC00996 chr7 150433654 150448140 + Display:

Experiment Detail

GEO ID: GSE98181 Sample Source: Blood Source Fraction: Serum Platform: GPL21572 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2546 Sample treatment protocol: Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes. RNA Extract protocol: RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water. RNA library preparation protocol: Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.

Reference

PMID: 29348816 Title: Development of a predictive miRNA signature for breast cancer risk among high-risk women. Author: Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME Journal: Oncotarget. 2017 Nov 28;8(68):112170-112183. Description: We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.