Entry Detail



General Information

Database ID:exR0357070
RNA Name:hsa-miR-423-5p
RNA Type:miRNA
Chromosome:chr17
Starnd:+
Coordinate:
Start Site(bp):30117095End Site(bp):30117117
External Links:hsa-miR-423-5p



Disease Information

Disease Name:Breast Cancer
Disease Category:Cancers
MeSH ID:D001943
Type:Neoplasms/Breast Neoplasms
Alias:Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast



Expression Detail

GEO ID:GSE98181
Description:Circulating miRNA profiles from serum of women at high-risk for breast cancer
Experimental Design:Cancer vs Control
Case Disease Type:Breast Cancer
Case Disease SubType:NA
Case Sample:Breast Cancer
Control Sample:Healthy
Number of Case:24
Number of Control:24
Number of Samples:48





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
DCAF7
chr17
63550477
63594279
+
PGAM1
chr10
97426191
97433444
+
MINK1
chr17
4833340
4898061
+
PSME3
chr17
42824385
42843760
+
LIMD2
chr17
63695888
63701172
-
SYVN1
chr11
65121780
65134533
-
KLC2
chr11
66257294
66267860
+
MYBL2
chr20
43667019
43716495
+
DLGAP4
chr20
36306336
36528637
+
CAPN15
chr16
527712
554636
+
MAPKBP1
chr15
41774434
41827855
+
PAK2
chr3
196739857
196832647
+
ACTN4
chr19
38647649
38731589
+
C1QTNF6
chr22
37180166
37199385
-
MAPK8IP2
chr22
50600793
50613981
+
BCORL1
chrX
129981107
130058083
+
FAM83H
chr8
143723933
143738234
-
WDR45B
chr17
82614562
82648553
-
CDCA7
chr2
173354820
173368997
+
PRR12
chr19
49591182
49626439
+
CHP1
chr15
41230839
41281887
+
TNFAIP3
chr6
137867214
137883312
+
IL2RB
chr22
37125843
37175054
-
RAB8A
chr19
16111889
16134234
+
HNRNPA2B1
chr7
26173057
26201529
-
ATN1
chr12
6924463
6942321
+
EIF5AL1
chr10
79512601
79516440
+
IGF2BP1
chr17
48997385
49056145
+
PPDPF
chr20
63520765
63522206
+
CTSD
chr11
1752755
1764573
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000540
chr14
55799534
55821940
+
hsa_circ_0001472
chr5
36953719
36976504
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC009133.5
chr16
29808679
29812227
+
AC016876.2
chr17
7581964
7584086
-
AC021078.1
chr5
149494314
149504670
-
AL356488.2
chr1
109100193
109100619
+
H19
chr11
1995176
2001470
-
KCNQ1OT1
chr11
2608328
2699994
-
MIR663AHG
chr20
26167817
26251546
-
MIRLET7BHG
chr22
46053869
46113928
+
NEAT1
chr11
65422774
65445540
+
STAG3L5P-PVRIG2P-PILRB
chr7
100336104
100367831
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE98181
Sample Source:Blood
Source Fraction:Serum
Platform:GPL21572
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2546
Sample treatment protocol:Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes.
RNA Extract protocol:RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water.
RNA library preparation protocol:Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.



Reference

PMID:29348816
Title:Development of a predictive miRNA signature for breast cancer risk among high-risk women.
Author:Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME
Journal:Oncotarget. 2017 Nov 28;8(68):112170-112183.
Description:We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.