exRNAdisease

Entry Detail

---



General Information

Database ID: exR0357148 RNA Name: hsa-miR-432-5p RNA Type: miRNA Chromosome: chr14 Starnd: + Coordinate: Start Site(bp): 100884496 End Site(bp): 100884518 External Links: hsa-miR-432-5p

Disease Information

Disease Name: Breast Cancer Disease Category: Cancers MeSH ID: D001943 Type: Neoplasms/Breast Neoplasms Alias: Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast

Expression Detail

GEO ID: GSE98181 Description: Circulating miRNA profiles from serum of women at high-risk for breast cancer Experimental Design: Cancer vs Control Case Disease Type: Breast Cancer Case Disease SubType: NA Case Sample: Breast Cancer Control Sample: Healthy Number of Case: 24 Number of Control: 24 Number of Samples: 48

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ABL1 chr9 130713016 130887675 + ANXA2 chr15 60347134 60402883 - ATP5MC3 chr2 175176258 175184607 - BLCAP chr20 37492472 37527931 - CA12 chr15 63321378 63381846 - CALM1 chr14 90396502 90408268 + CELSR2 chr1 109249539 109275751 + CHTF8 chr16 69118010 69132578 - DNAJC13 chr3 132417502 132539032 + EPB41 chr1 28887091 29120046 + FADS2 chr11 61792980 61867354 + FN1 chr2 215360440 215436073 - GGA3 chr17 75236599 75262363 - GNAI2 chr3 50226292 50259362 + HMBOX1 chr8 28890395 29064764 + IGF1R chr15 98648539 98964530 + IPO9 chr1 201829149 201884291 + KDM3B chr5 138352685 138437028 + MFHAS1 chr8 8783354 8893630 - NAPEPLD chr7 103099776 103149560 - PHC3 chr3 170086732 170181749 - PRELID3B chr20 59033145 59042809 - PTCD3 chr2 86106223 86142157 + RASA1 chr5 87267883 87391931 + SETD7 chr4 139495941 139606699 - STAMBP chr2 73828916 73873659 + TMEM63A chr1 225845536 225882380 - TOB2 chr22 41433494 41446801 - ZBTB34 chr9 126860665 126885878 + ZNF12 chr7 6688433 6706947 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001454 chr4 154524454 154533552 + hsa_circ_0001349 chr3 152132729 152150709 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC009133.5 chr16 29808679 29812227 + AC016876.2 chr17 7581964 7584086 - AC068768.1 chr12 123262060 123262402 + AC239868.1 chr1 149861271 149862504 + KCNQ1OT1 chr11 2608328 2699994 - LINC00649 chr21 33915534 33977691 + NEAT1 chr11 65422774 65445540 + PCBP2-OT1 chr12 53464468 53465057 + SNHG16 chr17 76557764 76565348 + XIST chrX 73820649 73852723 - ZFAS1 chr20 49278178 49299600 + Display:

Experiment Detail

GEO ID: GSE98181 Sample Source: Blood Source Fraction: Serum Platform: GPL21572 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2546 Sample treatment protocol: Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes. RNA Extract protocol: RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water. RNA library preparation protocol: Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.

Reference

PMID: 29348816 Title: Development of a predictive miRNA signature for breast cancer risk among high-risk women. Author: Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME Journal: Oncotarget. 2017 Nov 28;8(68):112170-112183. Description: We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.