exRNAdisease

Entry Detail

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General Information

Database ID: exR0357170 RNA Name: hsa-miR-4426 RNA Type: miRNA Chromosome: chr1 Starnd: + Coordinate: Start Site(bp): 192716333 End Site(bp): 192716349 External Links: hsa-miR-4426

Disease Information

Disease Name: Breast Cancer Disease Category: Cancers MeSH ID: D001943 Type: Neoplasms/Breast Neoplasms Alias: Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast

Expression Detail

GEO ID: GSE98181 Description: Circulating miRNA profiles from serum of women at high-risk for breast cancer Experimental Design: Cancer vs Control Case Disease Type: Breast Cancer Case Disease SubType: NA Case Sample: Breast Cancer Control Sample: Healthy Number of Case: 24 Number of Control: 24 Number of Samples: 48

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand UFC1 chr1 161152776 161158856 + NDUFA4 chr7 10931943 10940153 - N4BP3 chr5 178113532 178126081 + MTRNR2L11 chr1 237943724 237945275 - RNF181 chr2 85595725 85597708 + VMP1 chr17 59707192 59842255 + DDB1 chr11 61299451 61342596 - SAP18 chr13 21140514 21149084 + DOCK6 chr19 11199295 11262524 - NSMAF chr8 58583508 58659853 - APP chr21 25880550 26171128 - TMEM170A chr16 75443054 75465497 - TKFC chr11 61333210 61353295 + CTSZ chr20 58995185 59007254 - AL136454.1 chr1 192716132 192716653 + TPT1 chr13 45333471 45341370 - PTPN6 chr12 6946468 6961316 + CAPNS1 chr19 36139953 36150353 + CCNL2 chr1 1385711 1399335 - RABGAP1L chr1 174159410 174995308 + RACK1 chr5 181236897 181248096 - HMGN2 chr1 26472440 26476642 + SEZ6L2 chr16 29871159 29899547 - GAPDH chr12 6534512 6538374 + CD52 chr1 26317958 26320523 + PCBP2 chr12 53452102 53481162 + NDUFA11 chr19 5891276 5904006 - REXO1 chr19 1815248 1848483 - ZNF655 chr7 99558406 99576453 + DCAF12 chr9 34086387 34127399 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC023509.1 chr12 53441741 53467528 + AC105942.1 chr1 94927361 94963616 + Display:

Experiment Detail

GEO ID: GSE98181 Sample Source: Blood Source Fraction: Serum Platform: GPL21572 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2546 Sample treatment protocol: Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes. RNA Extract protocol: RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water. RNA library preparation protocol: Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.

Reference

PMID: 29348816 Title: Development of a predictive miRNA signature for breast cancer risk among high-risk women. Author: Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME Journal: Oncotarget. 2017 Nov 28;8(68):112170-112183. Description: We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.