exRNAdisease

Entry Detail

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General Information

Database ID: exR0357237 RNA Name: hsa-miR-4485-3p RNA Type: miRNA Chromosome: chr11 Starnd: - Coordinate: Start Site(bp): 10508277 End Site(bp): 10508296 External Links: hsa-miR-4485-3p

Disease Information

Disease Name: Breast Cancer Disease Category: Cancers MeSH ID: D001943 Type: Neoplasms/Breast Neoplasms Alias: Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast

Expression Detail

GEO ID: GSE98181 Description: Circulating miRNA profiles from serum of women at high-risk for breast cancer Experimental Design: Cancer vs Control Case Disease Type: Breast Cancer Case Disease SubType: NA Case Sample: Breast Cancer Control Sample: Healthy Number of Case: 24 Number of Control: 24 Number of Samples: 48

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand C11orf24 chr11 68261338 68272001 - CDK4 chr12 57747727 57756013 - CKAP5 chr11 46743048 46846308 - CYB561A3 chr11 61348745 61362299 - SERINC1 chr6 122443351 122471807 - NES chr1 156668763 156677407 - NDUFB11 chrX 47142216 47145504 - FUBP1 chr1 77944055 77979110 - RPL27 chr17 42998273 43002959 + YEATS2 chr3 183697797 183812624 + CIRBP chr19 1259384 1274880 + DNM1 chr9 128191655 128255248 + MAP3K11 chr11 65597756 65615382 - RPL13 chr16 89560657 89566828 + EXOSC6 chr16 70246778 70251940 - SBF2 chr11 9778667 10294207 - HSPA8 chr11 123057489 123063230 - RPS27A chr2 55231903 55235853 + EIF3F chr11 7970251 8001862 + RNASEH2C chr11 65714005 65720818 - FAU chr11 65120630 65122177 - HSP90AB1 chr6 44246166 44253888 + RPS3 chr11 75399515 75422280 + NR3C1 chr5 143277931 143435512 - SPG11 chr15 44562696 44663678 - MTRNR2L6 chr7 142666272 142667718 + LGR4 chr11 27365961 27472790 - FRMD8 chr11 65386621 65413525 + CRTC3 chr15 90529923 90645345 + MTRNR2L12 chr3 96617188 96618236 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand MALAT1 chr11 65497688 65506516 + XIST chrX 73820649 73852723 - AD000090.1 chr19 35557956 35581954 + LINC01002 chr19 198264 246544 - Display:

Experiment Detail

GEO ID: GSE98181 Sample Source: Blood Source Fraction: Serum Platform: GPL21572 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2546 Sample treatment protocol: Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes. RNA Extract protocol: RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water. RNA library preparation protocol: Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.

Reference

PMID: 29348816 Title: Development of a predictive miRNA signature for breast cancer risk among high-risk women. Author: Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME Journal: Oncotarget. 2017 Nov 28;8(68):112170-112183. Description: We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.