Entry Detail



General Information

Database ID:exR0357254
RNA Name:hsa-miR-449b-5p
RNA Type:miRNA
Chromosome:chr5
Starnd:-
Coordinate:
Start Site(bp):55170706End Site(bp):55170727
External Links:hsa-miR-449b-5p



Disease Information

Disease Name:Breast Cancer
Disease Category:Cancers
MeSH ID:D001943
Type:Neoplasms/Breast Neoplasms
Alias:Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast



Expression Detail

GEO ID:GSE98181
Description:Circulating miRNA profiles from serum of women at high-risk for breast cancer
Experimental Design:Cancer vs Control
Case Disease Type:Breast Cancer
Case Disease SubType:NA
Case Sample:Breast Cancer
Control Sample:Healthy
Number of Case:24
Number of Control:24
Number of Samples:48





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
MID1
chrX
10445310
10833654
-
JPH1
chr8
74234700
74321540
-
TAOK1
chr17
29390464
29551904
+
DEDD2
chr19
42198598
42220140
-
PTPRJ
chr11
47980558
48170841
+
GNA12
chr7
2728105
2844308
-
HNRNPUL1
chr19
41262496
41307787
+
ZNF623
chr8
143636013
143656418
+
SUPT6H
chr17
28662198
28702679
+
NCOR1
chr17
16029157
16218185
-
IGSF3
chr1
116574399
116667755
-
ANKRD52
chr12
56237807
56258384
-
ESS2
chr22
19130279
19144684
-
TNRC6B
chr22
40044817
40335808
+
ZIC5
chr13
99962964
99971909
-
JRK
chr8
142657460
142681968
-
GATAD2B
chr1
153789030
153923360
-
ATXN7L3
chr17
44191805
44200113
-
AMER1
chrX
64185117
64205708
-
STK38L
chr12
27243968
27325959
+
SH3PXD2A
chr10
103594027
103855543
-
CD151
chr11
832887
839831
+
NPTX1
chr17
80466834
80477843
-
MYCN
chr2
15940550
15947007
+
NDST1
chr5
150485818
150558211
+
TMEM109
chr11
60914158
60923443
+
ERGIC1
chr5
172834251
172952683
+
RTL8B
chrX
135020513
135022542
-
FGFRL1
chr4
1009936
1026898
+
IL2RB
chr22
37125843
37175054
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001723
chr7
91924202
91948826
+
hsa_circ_0001495
chr5
68470703
68471364
+
hsa_circ_0000943
chr19
47421744
47440665
+
hsa_circ_0000038
chr1
28800065
28802803
+
hsa_circ_0001865
chr9
86292641
86293514
-
hsa_circ_0001146
chr20
34241449
34246936
-
hsa_circ_0001164
chr20
45891031
45923523
-
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC018521.1
chr17
47945424
47981736
+
AC116913.1
chr15
66488658
66492109
-
HCG18
chr6
30286690
30327382
-
KCNQ1OT1
chr11
2608328
2699994
-
LINC00665
chr19
36313067
36331770
-
NEAT1
chr11
65422774
65445540
+
SNHG7
chr9
136721366
136728184
-
TERC
chr3
169764520
169765060
-
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE98181
Sample Source:Blood
Source Fraction:Serum
Platform:GPL21572
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2546
Sample treatment protocol:Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes.
RNA Extract protocol:RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water.
RNA library preparation protocol:Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.



Reference

PMID:29348816
Title:Development of a predictive miRNA signature for breast cancer risk among high-risk women.
Author:Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME
Journal:Oncotarget. 2017 Nov 28;8(68):112170-112183.
Description:We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.