exRNAdisease

Entry Detail

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General Information

Database ID: exR0357265 RNA Name: hsa-miR-4508 RNA Type: miRNA Chromosome: chr15 Starnd: - Coordinate: Start Site(bp): 23562107 End Site(bp): 23562123 External Links: hsa-miR-4508

Disease Information

Disease Name: Breast Cancer Disease Category: Cancers MeSH ID: D001943 Type: Neoplasms/Breast Neoplasms Alias: Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast

Expression Detail

GEO ID: GSE98181 Description: Circulating miRNA profiles from serum of women at high-risk for breast cancer Experimental Design: Cancer vs Control Case Disease Type: Breast Cancer Case Disease SubType: NA Case Sample: Breast Cancer Control Sample: Healthy Number of Case: 24 Number of Control: 24 Number of Samples: 48

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand USP22 chr17 20999596 21043760 - AC005943.1 chr19 1578339 1605445 - ADNP2 chr18 80109262 80147523 + ANAPC1 chr2 111611639 111884690 - ANKRD54 chr22 37830855 37849327 - CDC42BPB chr14 102932380 103057549 - COA1 chr7 43608456 43729717 - CSNK1G2 chr19 1941172 1981338 + CTC1 chr17 8224815 8248056 - EID2 chr19 39538707 39540161 - ESYT2 chr7 158730995 158830253 - FUS chr16 31180110 31194871 + LTBP3 chr11 65538805 65558930 - MBD3 chr19 1573596 1592865 - NDUFB4 chr3 120596328 120602507 + OXTR chr3 8750408 8769628 - PROB1 chr5 139390592 139395104 - SCAF4 chr21 31671000 31732118 - SLBP chr4 1692731 1712344 - TM9SF1 chr14 24189149 24195687 - TMCO3 chr13 113491021 113554590 + UBE3A chr15 25333728 25439051 - URI1 chr19 29923644 30016612 + UROS chr10 125784980 125823258 - USP28 chr11 113797874 113875570 - WRAP53 chr17 7686071 7703502 + ZNF580 chr19 55635016 55643470 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand HCG18 chr6 30286690 30327382 - Display:

Experiment Detail

GEO ID: GSE98181 Sample Source: Blood Source Fraction: Serum Platform: GPL21572 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2546 Sample treatment protocol: Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes. RNA Extract protocol: RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water. RNA library preparation protocol: Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.

Reference

PMID: 29348816 Title: Development of a predictive miRNA signature for breast cancer risk among high-risk women. Author: Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME Journal: Oncotarget. 2017 Nov 28;8(68):112170-112183. Description: We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.