exRNAdisease

Entry Detail

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General Information

Database ID: exR0357440 RNA Name: hsa-miR-4709-5p RNA Type: miRNA Chromosome: chr14 Starnd: - Coordinate: Start Site(bp): 74480175 End Site(bp): 74480196 External Links: hsa-miR-4709-5p

Disease Information

Disease Name: Breast Cancer Disease Category: Cancers MeSH ID: D001943 Type: Neoplasms/Breast Neoplasms Alias: Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast

Expression Detail

GEO ID: GSE98181 Description: Circulating miRNA profiles from serum of women at high-risk for breast cancer Experimental Design: Cancer vs Control Case Disease Type: Breast Cancer Case Disease SubType: NA Case Sample: Breast Cancer Control Sample: Healthy Number of Case: 24 Number of Control: 24 Number of Samples: 48

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand BCORL1 chrX 129981107 130058083 + CBX2 chr17 79778148 79787983 + CTNND1 chr11 57753243 57819546 + DNAJB6 chr7 157335381 157417439 + ERP29 chr12 112013348 112023449 + LAMC1 chr1 183023420 183145592 + ARID4B chr1 235131634 235328219 - CLSTN3 chr12 7129698 7158945 + DHX16 chr6 30653119 30673006 - GFM2 chr5 74721206 74767147 - HNRNPL chr19 38836388 38852347 - HOXB13 chr17 48724763 48729178 - HSP90AA1 chr14 102080738 102139699 - IDH1 chr2 208236227 208266074 - IREB2 chr15 78437431 78501453 + MKKS chr20 10401009 10434222 - MSH3 chr5 80654652 80876815 + NPC2 chr14 74476192 74494177 - PABPC1 chr8 100685816 100722809 - PODXL chr7 131500262 131558217 - PRDX5 chr11 64318121 64321811 + SCAF8 chr6 154733325 154834244 + TIAM2 chr6 154832697 155257723 + UGP2 chr2 63840940 63891562 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC005479.1 chr14 74474007 74474864 - Display:

Experiment Detail

GEO ID: GSE98181 Sample Source: Blood Source Fraction: Serum Platform: GPL21572 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2546 Sample treatment protocol: Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes. RNA Extract protocol: RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water. RNA library preparation protocol: Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.

Reference

PMID: 29348816 Title: Development of a predictive miRNA signature for breast cancer risk among high-risk women. Author: Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME Journal: Oncotarget. 2017 Nov 28;8(68):112170-112183. Description: We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.