exRNAdisease

Entry Detail

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General Information

Database ID: exR0357615 RNA Name: hsa-miR-491-5p RNA Type: miRNA Chromosome: chr9 Starnd: + Coordinate: Start Site(bp): 20716120 End Site(bp): 20716141 External Links: hsa-miR-491-5p

Disease Information

Disease Name: Breast Cancer Disease Category: Cancers MeSH ID: D001943 Type: Neoplasms/Breast Neoplasms Alias: Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast

Expression Detail

GEO ID: GSE98181 Description: Circulating miRNA profiles from serum of women at high-risk for breast cancer Experimental Design: Cancer vs Control Case Disease Type: Breast Cancer Case Disease SubType: NA Case Sample: Breast Cancer Control Sample: Healthy Number of Case: 24 Number of Control: 24 Number of Samples: 48

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand IGFBP4 chr17 40443450 40457725 + SRF chr6 43171269 43181506 + CDR2L chr17 74987632 75005800 + CENPB chr20 3783851 3786740 - RBFOX2 chr22 35738736 36028824 - SPRED2 chr2 65310851 65432637 - PHB2 chr12 6965327 6970753 - PTPRU chr1 29236516 29326813 + PTBP3 chr9 112217716 112333667 - SLC6A6 chr3 14402576 14489349 + SNAI1 chr20 49982980 49988886 + NDST1 chr5 150485818 150558211 + PPP4C chr16 30075978 30085376 + LIMD2 chr17 63695888 63701172 - TTPAL chr20 44475874 44494603 + SAMD4B chr19 39342396 39385710 + QSOX2 chr9 136206333 136245812 - C19orf47 chr19 40319536 40348527 - ZNF574 chr19 42068477 42081552 + PDXP chr22 37658723 37666932 + MEF2D chr1 156463727 156500779 - TP53 chr17 7661779 7687550 - ATXN7L3 chr17 44191805 44200113 - CPSF7 chr11 61402641 61430031 - CD151 chr11 832887 839831 + DIRAS1 chr19 2714567 2721372 - COL4A2 chr13 110305812 110513209 + NOTCH2 chr1 119911553 120100779 - INTS2 chr17 61865367 61928016 - HDGF chr1 156742109 156766925 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000128 chr1 151139409 151139890 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC016876.2 chr17 7581964 7584086 - AC023509.1 chr12 53441741 53467528 + AC069281.2 chr7 100572232 100578700 - AL355987.2 chr9 136800366 136829466 + AL645608.6 chr1 904834 915976 + H19 chr11 1995176 2001470 - LINC01278 chrX 63222993 63561095 - MALAT1 chr11 65497688 65506516 + NEAT1 chr11 65422774 65445540 + PCBP2-OT1 chr12 53464468 53465057 + VPS9D1-AS1 chr16 89711856 89718165 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE98181 Sample Source: Blood Source Fraction: Serum Platform: GPL21572 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2546 Sample treatment protocol: Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes. RNA Extract protocol: RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water. RNA library preparation protocol: Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.

Reference

PMID: 29348816 Title: Development of a predictive miRNA signature for breast cancer risk among high-risk women. Author: Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME Journal: Oncotarget. 2017 Nov 28;8(68):112170-112183. Description: We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.