Entry Detail



General Information

Database ID:exR0357747
RNA Name:hsa-miR-519c-3p
RNA Type:miRNA
Chromosome:chr19
Starnd:+
Coordinate:
Start Site(bp):53686522End Site(bp):53686543
External Links:hsa-miR-519c-3p



Disease Information

Disease Name:Breast Cancer
Disease Category:Cancers
MeSH ID:D001943
Type:Neoplasms/Breast Neoplasms
Alias:Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast



Expression Detail

GEO ID:GSE98181
Description:Circulating miRNA profiles from serum of women at high-risk for breast cancer
Experimental Design:Cancer vs Control
Case Disease Type:Breast Cancer
Case Disease SubType:NA
Case Sample:Breast Cancer
Control Sample:Healthy
Number of Case:24
Number of Control:24
Number of Samples:48





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ADAR
chr1
154582057
154628013
-
ARL4A
chr7
12686856
12690958
+
CCDC93
chr2
117915478
118014133
-
CCSAP
chr1
229321011
229343294
-
CHD9
chr16
53055033
53329150
+
CLCN6
chr1
11806096
11848079
+
CLIP4
chr2
29097705
29189643
+
EEA1
chr12
92770637
92929331
-
EIF5A2
chr3
170888418
170908644
-
FAM13A
chr4
88725955
89111398
-
JPT1
chr17
75135248
75168281
-
KLHL28
chr14
44924319
45042322
-
MAGI3
chr1
113390515
113685923
+
MTF1
chr1
37809574
37859592
-
NPAS2
chr2
100820139
100996829
+
RCCD1
chr15
90954870
90963125
+
SEC16A
chr9
136440096
136483759
-
SLC16A14
chr2
230034982
230068993
-
SLC46A3
chr13
28700064
28718970
-
SMAD7
chr18
48919853
48952052
-
SYAP1
chrX
16719612
16765340
+
TAOK3
chr12
118149801
118372907
-
TMEM50A
chr1
25338317
25362361
+
ZFAND4
chr10
45615500
45672780
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001495
chr5
68470703
68471364
+
hsa_circ_0000494
chr13
76134888
76143643
+
hsa_circ_0000018
chr1
15860731
15863309
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC002094.1
chr17
28357647
28381697
+
AC010542.4
chr16
66549280
66551189
+
AC015871.3
chr15
79920195
79922455
-
AC021078.1
chr5
149494314
149504670
-
AC021092.1
chr19
44103007
44113183
-
AC024940.6
chr12
31280422
31280895
-
AC087477.2
chr15
96354237
96405235
+
AC243964.3
chr19
44631573
44725217
-
AL137782.1
chr13
75549773
75807120
+
AL158206.1
chr9
19453209
19455173
+
CKMT2-AS1
chr5
81201341
81301565
-
EPB41L4A-AS1
chr5
112160526
112164818
+
ERICD
chr8
140636281
140638283
+
H19
chr11
1995176
2001470
-
HAGLR
chr2
176164051
176188958
-
HOTAIR
chr12
53962308
53974956
-
MAGI2-AS3
chr7
79452877
79471208
+
MIR17HG
chr13
91347820
91354579
+
NEAT1
chr11
65422774
65445540
+
STAG3L5P-PVRIG2P-PILRB
chr7
100336104
100367831
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE98181
Sample Source:Blood
Source Fraction:Serum
Platform:GPL21572
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2546
Sample treatment protocol:Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes.
RNA Extract protocol:RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water.
RNA library preparation protocol:Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.



Reference

PMID:29348816
Title:Development of a predictive miRNA signature for breast cancer risk among high-risk women.
Author:Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME
Journal:Oncotarget. 2017 Nov 28;8(68):112170-112183.
Description:We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.