exRNAdisease

General Information

Database ID:

exR0357963

RNA Name:

hsa-miR-574-5p

RNA Type:

miRNA

Chromosome:

chr4

Starnd:

Coordinate:

Start Site(bp):

38868056

End Site(bp):

38868078

External Links:

Disease Information

Disease Name:	Breast Cancer
Disease Category:	Cancers
MeSH ID:	D001943
Type:	Neoplasms/Breast Neoplasms
Alias:	Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast

Expression Detail

GEO ID:	GSE98181
Description:	Circulating miRNA profiles from serum of women at high-risk for breast cancer
Experimental Design:	Cancer vs Control
Case Disease Type:	Breast Cancer
Case Disease SubType:	NA
Case Sample:	Breast Cancer
Control Sample:	Healthy
Number of Case:	24
Number of Control:	24
Number of Samples:	48

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
CCDC88C	chr14	91271323	91417844	-
CARMIL1	chr6	25279078	25620530	+
AHCYL1	chr1	109984765	110023742	+
ARID3A	chr19	925781	975939	+
CHD7	chr8	60678740	60868028	+
IDH3A	chr15	78131498	78171945	+
FAM102A	chr9	127940582	127980989	-
EEF2K	chr16	22206278	22288738	+
LRP8	chr1	53242364	53328469	-
SMCO4	chr11	93478472	93543391	-
ALDOA	chr16	30064164	30070457	+
ZNF621	chr3	40524878	40574685	+
MAP7D1	chr1	36155579	36180849	+
RAB10	chr2	26034084	26137454	+
TACC1	chr8	38728186	38853028	+
KLF11	chr2	10042849	10054836	+
TEAD1	chr11	12674421	12944737	+
MGRN1	chr16	4616493	4690974	+
SLC9A1	chr1	27098809	27166981	-
FNDC3A	chr13	48975912	49209779	+
SLC25A43	chrX	119399336	119454478	+
CTSD	chr11	1752755	1764573	-
PHF20L1	chr8	132775358	132848807	+
DCAF8	chr1	160215715	160262549	-
PIK3R3	chr1	46040140	46133036	-
RHOU	chr1	228735479	228746664	+
GALNT3	chr2	165747588	165794659	-
HOXC8	chr12	54008985	54012769	+
NID1	chr1	235975830	236065109	-
WSB2	chr12	118032694	118062430	-

miRNA targets:

circRNA targets:

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC005394.2	chr19	28435388	28727680	-
AC021092.1	chr19	44103007	44113183	-
AL358472.3	chr1	153966516	153966930	+
DSCAM-AS1	chr21	40383083	40385358	+
NEAT1	chr11	65422774	65445540	+
SNHG7	chr9	136721366	136728184	-
XIST	chrX	73820649	73852723	-

Display:

Experiment Detail

GEO ID:	GSE98181
Sample Source:	Blood
Source Fraction:	Serum
Platform:	GPL21572
Method:	Microarray
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	2546
Sample treatment protocol:	Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes.
RNA Extract protocol:	RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water.
RNA library preparation protocol:	Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.

Reference

PMID:	29348816
Title:	Development of a predictive miRNA signature for breast cancer risk among high-risk women.
Author:	Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME
Journal:	Oncotarget. 2017 Nov 28;8(68):112170-112183.
Description:	We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.