exRNAdisease

General Information

Database ID:

exR0357984

RNA Name:

hsa-miR-588

RNA Type:

miRNA

Chromosome:

chr6

Starnd:

Coordinate:

Start Site(bp):

126484646

End Site(bp):

126484666

External Links:

Disease Information

Disease Name:	Breast Cancer
Disease Category:	Cancers
MeSH ID:	D001943
Type:	Neoplasms/Breast Neoplasms
Alias:	Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast

Expression Detail

GEO ID:	GSE98181
Description:	Circulating miRNA profiles from serum of women at high-risk for breast cancer
Experimental Design:	Cancer vs Control
Case Disease Type:	Breast Cancer
Case Disease SubType:	NA
Case Sample:	Breast Cancer
Control Sample:	Healthy
Number of Case:	24
Number of Control:	24
Number of Samples:	48

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
ADGRE5	chr19	14380501	14408725	+
ARHGDIA	chr17	81867721	81871378	-
EDEM3	chr1	184690237	184754907	-
EIF1AD	chr11	65996545	66002176	-
FURIN	chr15	90868588	90883458	+
GLIS2	chr16	4314761	4339597	+
NID1	chr1	235975830	236065109	-
NIP7	chr16	69337996	69343106	+
NT5DC3	chr12	103770453	103841234	-
STK40	chr1	36339624	36385896	-
TSPAN14	chr10	80454166	80533124	+
TUB	chr11	8019244	8106112	+
ZBTB39	chr12	56998836	57006546	-

miRNA targets:

circRNA targets:

circRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa_circ_0001025	chr2	69565029	69565697	-
hsa_circ_0000384	chr12	27867712	27877119	+
hsa_circ_0001247	chr22	46125304	46136418	+
hsa_circ_0000284	chr11	33307958	33309057	+
hsa_circ_0000126	chr1	150997086	150999803	+
hsa_circ_0000744	chr17	15968183	15971435	-

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC007161.3	chr7	7640752	8004053	+
AL022311.1	chr22	37876148	37895563	+
AL359924.1	chr1	237862175	237928321	+
H19	chr11	1995176	2001470	-
MIR497HG	chr17	7015818	7019659	-
NEAT1	chr11	65422774	65445540	+
PINK1-AS	chr1	20642657	20652193	-
SNHG8	chr4	118278709	118285316	+
XIST	chrX	73820649	73852723	-

Display:

Experiment Detail

GEO ID:	GSE98181
Sample Source:	Blood
Source Fraction:	Serum
Platform:	GPL21572
Method:	Microarray
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	2546
Sample treatment protocol:	Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes.
RNA Extract protocol:	RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water.
RNA library preparation protocol:	Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.

Reference

PMID:	29348816
Title:	Development of a predictive miRNA signature for breast cancer risk among high-risk women.
Author:	Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME
Journal:	Oncotarget. 2017 Nov 28;8(68):112170-112183.
Description:	We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.