Entry Detail



General Information

Database ID:exR0358098
RNA Name:hsa-miR-650
RNA Type:miRNA
Chromosome:chr22
Starnd:+
Coordinate:
Start Site(bp):22822791End Site(bp):22822811
External Links:hsa-miR-650



Disease Information

Disease Name:Breast Cancer
Disease Category:Cancers
MeSH ID:D001943
Type:Neoplasms/Breast Neoplasms
Alias:Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast



Expression Detail

GEO ID:GSE98181
Description:Circulating miRNA profiles from serum of women at high-risk for breast cancer
Experimental Design:Cancer vs Control
Case Disease Type:Breast Cancer
Case Disease SubType:NA
Case Sample:Breast Cancer
Control Sample:Healthy
Number of Case:24
Number of Control:24
Number of Samples:48





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
POM121C
chr7
75416786
75486299
-
ATXN2L
chr16
28823035
28837237
+
RNF220
chr1
44405194
44651724
+
POLE3
chr9
113407235
113410675
-
SFN
chr1
26863149
26864456
+
SH3GL1
chr19
4360370
4400547
-
STOM
chr9
121338987
121370304
-
HNRNPUL1
chr19
41262496
41307787
+
LMNA
chr1
156082573
156140089
+
SLC9A3R1
chr17
74748628
74769353
+
HPCAL1
chr2
10302889
10427617
+
TRAF7
chr16
2155698
2178129
+
GBF1
chr10
102245532
102382899
+
ZNF623
chr8
143636013
143656418
+
USP22
chr17
20999596
21043760
-
POLDIP3
chr22
42583721
42614962
-
VHL
chr3
10141008
10152220
+
ABL1
chr9
130713016
130887675
+
TSKU
chr11
76782251
76798153
+
TRAPPC10
chr21
44012309
44106552
+
SLC29A1
chr6
44219553
44234142
+
HIF1AN
chr10
100529072
100559998
+
NBL1
chr1
19596979
19658456
+
AFAP1
chr4
7758714
7939926
-
CBFA2T3
chr16
88874858
88977207
-
AKT2
chr19
40230317
40285536
-
RAB1B
chr11
66268590
66277492
+
PAK4
chr19
39125770
39182816
+
DUSP8
chr11
1554051
1572271
-
TESMIN
chr11
68707440
68751520
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001168
chr20
47691321
47707559
+
hsa_circ_0001146
chr20
34241449
34246936
-
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC068768.1
chr12
123262060
123262402
+
AC118758.3
chr7
56809214
56848800
-
AL049796.1
chr1
93847174
93848939
+
AL355075.4
chr14
20343048
20343685
-
DSCAM-AS1
chr21
40383083
40385358
+
KCNQ1OT1
chr11
2608328
2699994
-
LINC01772
chr1
16460948
16468481
+
MIR155HG
chr21
25561909
25575168
+
MIR663AHG
chr20
26167817
26251546
-
NEAT1
chr11
65422774
65445540
+
TUG1
chr22
30969245
30979395
+
Display:



Experiment Detail

GEO ID:GSE98181
Sample Source:Blood
Source Fraction:Serum
Platform:GPL21572
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2546
Sample treatment protocol:Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes.
RNA Extract protocol:RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water.
RNA library preparation protocol:Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.



Reference

PMID:29348816
Title:Development of a predictive miRNA signature for breast cancer risk among high-risk women.
Author:Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME
Journal:Oncotarget. 2017 Nov 28;8(68):112170-112183.
Description:We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.