Entry Detail



General Information

Database ID:exR0358161
RNA Name:hsa-miR-665
RNA Type:miRNA
Chromosome:chr14
Starnd:+
Coordinate:
Start Site(bp):100875075End Site(bp):100875094
External Links:hsa-miR-665



Disease Information

Disease Name:Breast Cancer
Disease Category:Cancers
MeSH ID:D001943
Type:Neoplasms/Breast Neoplasms
Alias:Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast



Expression Detail

GEO ID:GSE98181
Description:Circulating miRNA profiles from serum of women at high-risk for breast cancer
Experimental Design:Cancer vs Control
Case Disease Type:Breast Cancer
Case Disease SubType:NA
Case Sample:Breast Cancer
Control Sample:Healthy
Number of Case:24
Number of Control:24
Number of Samples:48





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
GINS1
chr20
25407673
25452628
+
TMED10
chr14
75131469
75176612
-
C19orf12
chr19
29698886
29715789
-
STX6
chr1
180972712
181023121
-
CTSD
chr11
1752755
1764573
-
CCNF
chr16
2429394
2458854
+
GREB1
chr2
11482341
11642788
+
IRF4
chr6
391752
411443
+
COX8A
chr11
63974620
63976543
+
ABHD2
chr15
89087459
89202355
+
CLDN11
chr3
170418865
170454733
+
ZNF527
chr19
37371061
37393066
+
ZBTB7A
chr19
4043303
4066899
-
TAF5L
chr1
229593111
229626047
-
CIPC
chr14
77098126
77117287
+
C6orf120
chr6
169702190
169704856
+
HADHA
chr2
26190635
26244672
-
EXOSC6
chr16
70246778
70251940
-
TSPAN4
chr11
842812
867116
+
EHD2
chr19
47713422
47743134
+
KLHDC3
chr6
43014103
43021298
+
CACUL1
chr10
118674167
118755249
-
RBM33
chr7
155644451
155781485
+
GUCD1
chr22
24540423
24555935
-
ELN
chr7
74027789
74069907
+
RHOF
chr12
121777754
121803403
-
VMA21
chrX
151396515
151409364
+
CBFB
chr16
67028984
67101058
+
STX3
chr11
59713456
59805882
+
TNFRSF1B
chr1
12166991
12209228
+
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000417
chr12
69644908
69656342
+
hsa_circ_0000402
chr12
53670403
53671011
+
hsa_circ_0000798
chr17
65941524
65944422
+
hsa_circ_0000943
chr19
47421744
47440665
+
hsa_circ_0001387
chr4
1902352
1936989
+
hsa_circ_0000799
chr17
65941524
65972074
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC005394.2
chr19
28435388
28727680
-
AC018521.1
chr17
47945424
47981736
+
AC023509.1
chr12
53441741
53467528
+
AC118758.3
chr7
56809214
56848800
-
AC234582.1
chr1
155195004
155205495
+
AL355987.4
chr9
136799223
136810042
+
ARHGAP27P1-BPTFP1-KPNA2P3
chr17
64749663
64781707
-
LINC00665
chr19
36313067
36331770
-
LINC00910
chr17
43338741
43389199
-
LINC01089
chr12
121795267
121803906
-
LINC01535
chr19
37251885
37265535
+
MIR29B2CHG
chr1
207801518
207879115
-
MIR497HG
chr17
7015818
7019659
-
NEAT1
chr11
65422774
65445540
+
OIP5-AS1
chr15
41283990
41309737
+
SND1-IT1
chr7
127997597
128000077
+
SNHG16
chr17
76557764
76565348
+
STAG3L5P-PVRIG2P-PILRB
chr7
100336104
100367831
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE98181
Sample Source:Blood
Source Fraction:Serum
Platform:GPL21572
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2546
Sample treatment protocol:Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes.
RNA Extract protocol:RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water.
RNA library preparation protocol:Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.



Reference

PMID:29348816
Title:Development of a predictive miRNA signature for breast cancer risk among high-risk women.
Author:Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME
Journal:Oncotarget. 2017 Nov 28;8(68):112170-112183.
Description:We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.