exRNAdisease

Entry Detail

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General Information

Database ID: exR0358529 RNA Name: hsa-miR-708-5p RNA Type: miRNA Chromosome: chr11 Starnd: - Coordinate: Start Site(bp): 79402077 End Site(bp): 79402099 External Links: hsa-miR-708-5p

Disease Information

Disease Name: Breast Cancer Disease Category: Cancers MeSH ID: D001943 Type: Neoplasms/Breast Neoplasms Alias: Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast

Expression Detail

GEO ID: GSE98181 Description: Circulating miRNA profiles from serum of women at high-risk for breast cancer Experimental Design: Cancer vs Control Case Disease Type: Breast Cancer Case Disease SubType: NA Case Sample: Breast Cancer Control Sample: Healthy Number of Case: 24 Number of Control: 24 Number of Samples: 48

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ANKRD52 chr12 56237807 56258384 - TUB chr11 8019244 8106112 + ERG28 chr14 75649791 75660876 - KIAA1522 chr1 32741830 32774970 + RGMA chr15 93035273 93089204 - RARG chr12 53210567 53232980 - GPCPD1 chr20 5544439 5611006 - ZBTB7B chr1 155002630 155018522 + GLYR1 chr16 4803203 4847288 - SMARCD1 chr12 50085200 50100707 + UBE2Z chr17 48908407 48929056 + SEH1L chr18 12947133 12987536 + LONRF2 chr2 100271875 100322501 - ENSA chr1 150600851 150629612 - PTMS chr12 6765516 6770952 + ATXN2L chr16 28823035 28837237 + FAM102A chr9 127940582 127980989 - TOB2 chr22 41433494 41446801 - SLC31A1 chr9 113221544 113264492 + PTPN23 chr3 47381011 47413435 + TEX261 chr2 70985942 70994873 - E2F4 chr16 67192155 67198918 + N4BP1 chr16 48538726 48620148 - FOXK1 chr7 4682295 4771442 + DYRK1A chr21 37365573 37526358 + E2F6 chr2 11444375 11466177 - CPSF2 chr14 92121969 92172145 + NAPA chr19 47487637 47515091 - MAPK1 chr22 21754500 21867680 - SMYD1 chr2 88067825 88113384 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000417 chr12 69644908 69656342 + hsa_circ_0001146 chr20 34241449 34246936 - hsa_circ_0001164 chr20 45891031 45923523 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC009065.4 chr16 2119207 2120248 + AC016876.2 chr17 7581964 7584086 - AC026362.1 chr12 122975320 122982907 + AC118758.3 chr7 56809214 56848800 - MALAT1 chr11 65497688 65506516 + NEAT1 chr11 65422774 65445540 + OIP5-AS1 chr15 41283990 41309737 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE98181 Sample Source: Blood Source Fraction: Serum Platform: GPL21572 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2546 Sample treatment protocol: Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes. RNA Extract protocol: RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water. RNA library preparation protocol: Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.

Reference

PMID: 29348816 Title: Development of a predictive miRNA signature for breast cancer risk among high-risk women. Author: Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME Journal: Oncotarget. 2017 Nov 28;8(68):112170-112183. Description: We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.