Entry Detail



General Information

Database ID:exR0358576
RNA Name:hsa-miR-744-5p
RNA Type:miRNA
Chromosome:chr17
Starnd:+
Coordinate:
Start Site(bp):12081909End Site(bp):12081930
External Links:hsa-miR-744-5p



Disease Information

Disease Name:Breast Cancer
Disease Category:Cancers
MeSH ID:D001943
Type:Neoplasms/Breast Neoplasms
Alias:Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast



Expression Detail

GEO ID:GSE98181
Description:Circulating miRNA profiles from serum of women at high-risk for breast cancer
Experimental Design:Cancer vs Control
Case Disease Type:Breast Cancer
Case Disease SubType:NA
Case Sample:Breast Cancer
Control Sample:Healthy
Number of Case:24
Number of Control:24
Number of Samples:48





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
AP5S1
chr20
3820524
3828838
+
ARHGDIA
chr17
81867721
81871378
-
ARL8A
chr1
202133404
202144743
-
C8orf82
chr8
144525733
144529132
-
CLSTN1
chr1
9728926
9823984
-
CMIP
chr16
81445170
81711762
+
DLGAP4
chr20
36306336
36528637
+
DNAJC30
chr7
73680918
73683453
-
EEF1A2
chr20
63488014
63499185
-
FAM219A
chr9
34398184
34458570
-
FAM83H
chr8
143723933
143738234
-
MGRN1
chr16
4616493
4690974
+
MIDN
chr19
1248553
1259140
+
NFIX
chr19
12995608
13098796
+
NRARP
chr9
137299631
137302271
-
PHB2
chr12
6965327
6970753
-
PRKCD
chr3
53156009
53192717
+
PRR12
chr19
49591182
49626439
+
RAI14
chr5
34656328
34832612
+
SCN1B
chr19
35030470
35040449
+
SH3GL1
chr19
4360370
4400547
-
SMAD3
chr15
67063763
67195169
+
SPRED2
chr2
65310851
65432637
-
SYVN1
chr11
65121780
65134533
-
WNT5A
chr3
55465715
55490539
-
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC002116.1
chr19
36008638
36014235
-
AC008738.7
chr19
33207129
33207639
+
AL356488.2
chr1
109100193
109100619
+
GAS5
chr1
173858559
173868882
-
Display:



Experiment Detail

GEO ID:GSE98181
Sample Source:Blood
Source Fraction:Serum
Platform:GPL21572
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2546
Sample treatment protocol:Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes.
RNA Extract protocol:RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water.
RNA library preparation protocol:Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.



Reference

PMID:29348816
Title:Development of a predictive miRNA signature for breast cancer risk among high-risk women.
Author:Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME
Journal:Oncotarget. 2017 Nov 28;8(68):112170-112183.
Description:We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.