exRNAdisease

General Information

Database ID:

exR0358730

RNA Name:

hsa-let-7e-5p

RNA Type:

miRNA

Chromosome:

chr19

Starnd:

Coordinate:

Start Site(bp):

51692793

End Site(bp):

51692814

External Links:

Disease Information

Disease Name:	Newborn Infant
Disease Category:	Other Diseases
MeSH ID:	D007231
Type:	Age Groups/Infant
Alias:	Infant, Newborn//Infants, Newborn//Newborn Infant//Newborn Infants//Newborns//Newborn//Neonate//Neonates

Expression Detail

GEO ID:	GSE65203
Description:	microRNA as a new immune-regulatory agent in breast milk
Experimental Design:	Disease vs Control
Case Disease Type:	Newborn Infant
Case Disease SubType:	NA
Case Sample:	Deliver < 28 days
Control Sample:	Deliver > 28 days
Number of Case:	2
Number of Control:	4
Number of Samples:	6

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
ARHGAP28	chr18	6729718	6915716	+
BACH1	chr21	29194071	29630751	+
BCAM	chr19	44809071	44821421	+
BLOC1S6	chr15	45587214	45615945	+
C15orf41	chr15	36579626	36810248	+
C19orf53	chr19	13774456	13778773	+
COIL	chr17	56938199	56961050	-
CTPS2	chrX	16587999	16712936	-
GRPEL2	chr5	149345430	149354583	+
HDLBP	chr2	241227264	241317061	-
HMGA1	chr6	34236873	34246231	+
IGDCC3	chr15	65327127	65378002	-
IGF2BP1	chr17	48997385	49056145	+
MNT	chr17	2384073	2401104	-
MPDZ	chr9	13105704	13279590	-
OPA3	chr19	45527427	45602212	-
PACS1	chr11	66070272	66244744	+
PDPR	chr16	70113626	70162537	+
PHC3	chr3	170086732	170181749	-
PLD3	chr19	40348456	40380439	+
PLPP6	chr9	4662294	4665258	+
PPARA	chr22	46150521	46243756	+
RAB40C	chr16	589357	629272	+
RANBP2	chr2	108719482	108785809	+
SH3PXD2B	chr5	172325000	172454525	-
TECPR2	chr14	102362941	102502477	+
TNRC6B	chr22	40044817	40335808	+
TRIM65	chr17	75880335	75896951	-
UBE2G2	chr21	44768580	44801826	-
YOD1	chr1	207043849	207052980	-

miRNA targets:

circRNA targets:

circRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa_circ_0000247	chr10	74474868	74475660	+
hsa_circ_0000987	chr2	30748452	30756180	+
hsa_circ_0000246	chr10	74468040	74475660	+
hsa_circ_0000018	chr1	15860731	15863309	+
hsa_circ_0000038	chr1	28800065	28802803	+
hsa_circ_0000799	chr17	65941524	65972074	+
hsa_circ_0001164	chr20	45891031	45923523	-

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC006064.5	chr12	6510275	6510522	+
AC074117.1	chr2	27356246	27367622	+
AC109460.3	chr16	28974804	28990775	+
AC124045.1	chr3	44667412	44669364	+
AP000766.1	chr11	107312132	107316271	-
ARHGAP27P1-BPTFP1-KPNA2P3	chr17	64749663	64781707	-
KCNQ1OT1	chr11	2608328	2699994	-
LINC00265	chr7	39733430	39793092	+
LINC02381	chr12	54126082	54147485	+
MIRLET7BHG	chr22	46053869	46113928	+
NEAT1	chr11	65422774	65445540	+
NUTM2A-AS1	chr10	87201647	87342612	-
SNHG16	chr17	76557764	76565348	+
SNHG4	chr5	139274102	139284899	+
TMPO-AS1	chr12	98512973	98516422	-
XIST	chrX	73820649	73852723	-
ZNF436-AS1	chr1	23368997	23371839	+

Display:

Experiment Detail

GEO ID:	GSE65203
Sample Source:	Breast Milk
Source Fraction:	Supernatant
Platform:	GPL7731
Method:	Microarray
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	548
Sample treatment protocol:	NA
RNA Extract protocol:	Total RNA extracted using mirVana miRNA isolation kit following manufacturer's instructions.
RNA library preparation protocol:	70 ng of each RNA sample was labeled with the miRNA Complete Labeling Reagent and Hybridization kit (Agilent Technologies) according to the manufacturer's instructions.

Reference

PMID:	20226005
Title:	microRNA as a new immune-regulatory agent in breast milk
Author:	Kosaka N, Izumi H, Sekine K, Ochiya T.
Journal:	Silence. 2010 Mar 1;1(1):7.
Description:	BACKGROUND: Breast milk is a complex liquid that provides nutrition to the infant and facilitates the maturation of the infant's immune system. Recent studies indicated that microRNA (miRNA) exists in human body fluid. Because miRNAs are known to regulate various immune systems, we hypothesized that human breast milk contains miRNAs that may be important for the development of the infant's immune system.