exRNAdisease

Entry Detail

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General Information

Database ID: exR0358775 RNA Name: hsa-miR-130b-3p RNA Type: miRNA Chromosome: chr22 Starnd: + Coordinate: Start Site(bp): 21653354 End Site(bp): 21653375 External Links: hsa-miR-130b-3p

Disease Information

Disease Name: Newborn Infant Disease Category: Other Diseases MeSH ID: D007231 Type: Age Groups/Infant Alias: Infant, Newborn//Infants, Newborn//Newborn Infant//Newborn Infants//Newborns//Newborn//Neonate//Neonates

Expression Detail

GEO ID: GSE65203 Description: microRNA as a new immune-regulatory agent in breast milk Experimental Design: Disease vs Control Case Disease Type: Newborn Infant Case Disease SubType: NA Case Sample: Deliver < 28 days Control Sample: Deliver > 28 days Number of Case: 2 Number of Control: 4 Number of Samples: 6

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand MLLT1 chr19 6210381 6279975 - XXYLT1 chr3 195068284 195271159 - STK38L chr12 27243968 27325959 + ZDHHC7 chr16 84974181 85011535 - OSBP chr11 59574398 59615774 - NPAS2 chr2 100820139 100996829 + G6PD chrX 154531391 154547572 - ANKRD52 chr12 56237807 56258384 - ADAR chr1 154582057 154628013 - ZC4H2 chrX 64915802 65034713 - SNX27 chr1 151612006 151699091 + USP47 chr11 11841423 11961887 + ZNF317 chr19 9140397 9163424 + GADD45A chr1 67685201 67688334 + ZBTB7B chr1 155002630 155018522 + CALU chr7 128739292 128773400 + PCYOX1 chr2 70257386 70281185 + MPPED2 chr11 30384493 30586872 - PDRG1 chr20 31944337 31952046 - CD151 chr11 832887 839831 + MGRN1 chr16 4616493 4690974 + TBC1D5 chr3 17157162 18444817 - ELOC chr8 73939169 73972287 - MSTO1 chr1 155610188 155614971 + IKZF4 chr12 56007659 56038435 + APOL6 chr22 35648446 35668404 + TRIM2 chr4 153152342 153339317 + SYNJ1 chr21 32628759 32728048 - RHOA chr3 49359145 49412998 - TGIF2 chr20 36573488 36593950 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000591 chr15 41961025 41962156 + hsa_circ_0001454 chr4 154524454 154533552 + hsa_circ_0000384 chr12 27867712 27877119 + hsa_circ_0001723 chr7 91924202 91948826 + hsa_circ_0000892 chr19 11941431 12014514 + hsa_circ_0001605 chr6 42903447 42905047 + hsa_circ_0000155 chr1 168007608 168014465 + hsa_circ_0001495 chr5 68470703 68471364 + hsa_circ_0000943 chr19 47421744 47440665 + hsa_circ_0000018 chr1 15860731 15863309 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC011503.2 chr19 23927788 23929287 + AC021092.1 chr19 44103007 44113183 - AC135050.6 chr16 31122235 31124064 + AC234582.1 chr1 155195004 155205495 + AL031595.3 chr22 44139365 44153626 + AL049840.4 chr14 103694516 103695050 - AL158206.1 chr9 19453209 19455173 + AL158825.2 chr9 75009828 75016036 - AL603839.3 chr1 40493157 40508661 - CKMT2-AS1 chr5 81201341 81301565 - H19 chr11 1995176 2001470 - HAGLR chr2 176164051 176188958 - KCNQ1OT1 chr11 2608328 2699994 - LINC01089 chr12 121795267 121803906 - MIR17HG chr13 91347820 91354579 + NEAT1 chr11 65422774 65445540 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE65203 Sample Source: Breast Milk Source Fraction: Supernatant Platform: GPL7731 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 548 Sample treatment protocol: NA RNA Extract protocol: Total RNA extracted using mirVana miRNA isolation kit following manufacturer's instructions. RNA library preparation protocol: 70 ng of each RNA sample was labeled with the miRNA Complete Labeling Reagent and Hybridization kit (Agilent Technologies) according to the manufacturer's instructions.

Reference

PMID: 20226005 Title: microRNA as a new immune-regulatory agent in breast milk Author: Kosaka N, Izumi H, Sekine K, Ochiya T. Journal: Silence. 2010 Mar 1;1(1):7. Description: BACKGROUND: Breast milk is a complex liquid that provides nutrition to the infant and facilitates the maturation of the infant's immune system. Recent studies indicated that microRNA (miRNA) exists in human body fluid. Because miRNAs are known to regulate various immune systems, we hypothesized that human breast milk contains miRNAs that may be important for the development of the infant's immune system.