exRNAdisease

Entry Detail

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General Information

Database ID: exR0358783 RNA Name: hsa-miR-135b-5p RNA Type: miRNA Chromosome: chr1 Starnd: - Coordinate: Start Site(bp): 205448361 End Site(bp): 205448383 External Links: hsa-miR-135b-5p

Disease Information

Disease Name: Newborn Infant Disease Category: Other Diseases MeSH ID: D007231 Type: Age Groups/Infant Alias: Infant, Newborn//Infants, Newborn//Newborn Infant//Newborn Infants//Newborns//Newborn//Neonate//Neonates

Expression Detail

GEO ID: GSE65203 Description: microRNA as a new immune-regulatory agent in breast milk Experimental Design: Disease vs Control Case Disease Type: Newborn Infant Case Disease SubType: NA Case Sample: Deliver < 28 days Control Sample: Deliver > 28 days Number of Case: 2 Number of Control: 4 Number of Samples: 6

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AP3M1 chr10 74120255 74151063 - APMAP chr20 24962925 24992751 - ARPP19 chr15 52547045 52569883 - MTDH chr8 97644184 97730260 + NECTIN1 chr11 119623408 119729200 - PHTF2 chr7 77798792 77957503 + PRRC2B chr9 131373636 131500197 + RAB11FIP5 chr2 73073382 73156721 - RPS23 chr5 82273320 82278396 - STK38 chr6 36493892 36547479 - STK4 chr20 44966479 45080021 + TMEM181 chr6 158536436 158635428 + TOB2 chr22 41433494 41446801 - ZBED4 chr22 49853844 49890080 + IARS2 chr1 220094132 220148041 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000540 chr14 55799534 55821940 + hsa_circ_0000471 chr13 33091993 33101669 - hsa_circ_0000527 chr14 24610097 24616430 - hsa_circ_0001168 chr20 47691321 47707559 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC005034.3 chr2 75697583 75697996 + AC009032.1 chr16 69632141 69632571 + AL137127.1 chr1 19072110 19075511 - DANCR chr4 52712404 52720351 + GAS5 chr1 173858559 173868882 - MALAT1 chr11 65497688 65506516 + NEAT1 chr11 65422774 65445540 + OIP5-AS1 chr15 41283990 41309737 + SPINT1-AS1 chr15 40835808 40844387 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE65203 Sample Source: Breast Milk Source Fraction: Supernatant Platform: GPL7731 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 548 Sample treatment protocol: NA RNA Extract protocol: Total RNA extracted using mirVana miRNA isolation kit following manufacturer's instructions. RNA library preparation protocol: 70 ng of each RNA sample was labeled with the miRNA Complete Labeling Reagent and Hybridization kit (Agilent Technologies) according to the manufacturer's instructions.

Reference

PMID: 20226005 Title: microRNA as a new immune-regulatory agent in breast milk Author: Kosaka N, Izumi H, Sekine K, Ochiya T. Journal: Silence. 2010 Mar 1;1(1):7. Description: BACKGROUND: Breast milk is a complex liquid that provides nutrition to the infant and facilitates the maturation of the infant's immune system. Recent studies indicated that microRNA (miRNA) exists in human body fluid. Because miRNAs are known to regulate various immune systems, we hypothesized that human breast milk contains miRNAs that may be important for the development of the infant's immune system.