exRNAdisease

Entry Detail

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General Information

Database ID: exR0358792 RNA Name: hsa-miR-142-3p RNA Type: miRNA Chromosome: chr17 Starnd: - Coordinate: Start Site(bp): 58331245 End Site(bp): 58331267 External Links: hsa-miR-142-3p

Disease Information

Disease Name: Newborn Infant Disease Category: Other Diseases MeSH ID: D007231 Type: Age Groups/Infant Alias: Infant, Newborn//Infants, Newborn//Newborn Infant//Newborn Infants//Newborns//Newborn//Neonate//Neonates

Expression Detail

GEO ID: GSE65203 Description: microRNA as a new immune-regulatory agent in breast milk Experimental Design: Disease vs Control Case Disease Type: Newborn Infant Case Disease SubType: NA Case Sample: Deliver < 28 days Control Sample: Deliver > 28 days Number of Case: 2 Number of Control: 4 Number of Samples: 6

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand BLOC1S6 chr15 45587214 45615945 + BOD1 chr5 173607145 173616659 - CUL5 chr11 108008898 108107761 + ETFRF1 chr12 25195216 25209645 + SEMA7A chr15 74409289 74433958 - TNRC6B chr22 40044817 40335808 + ZNF676 chr19 22179089 22215801 - AL139011.2 chr1 160216800 160285130 - B2M chr15 44711487 44718877 + CCDC126 chr7 23597382 23644708 + EEF1A1 chr6 73515750 73523797 - MAST2 chr1 45786987 46036122 + MBD3 chr19 1573596 1592865 - MRPL18 chr6 159789812 159798436 + NDUFA2 chr5 140638740 140647785 - PEX19 chr1 160276812 160286348 - PRDX1 chr1 45511036 45523047 - RPL27 chr17 42998273 43002959 + SLC35F5 chr2 113705011 113756693 - SPDL1 chr5 169583636 169604778 + TMSB4X chrX 12975110 12977227 + VPS53 chr17 508668 721717 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000120 chr1 117944807 118009049 + hsa_circ_0001387 chr4 1902352 1936989 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC004687.1 chr17 58330884 58332508 - AC011815.1 chr18 35280867 35290201 - AC126365.1 chr17 20788071 20789584 + FGD5-AS1 chr3 14920347 14948424 - MALAT1 chr11 65497688 65506516 + NEAT1 chr11 65422774 65445540 + AC138761.1 chr17 22266395 22288301 + Display:

Experiment Detail

GEO ID: GSE65203 Sample Source: Breast Milk Source Fraction: Supernatant Platform: GPL7731 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 548 Sample treatment protocol: NA RNA Extract protocol: Total RNA extracted using mirVana miRNA isolation kit following manufacturer's instructions. RNA library preparation protocol: 70 ng of each RNA sample was labeled with the miRNA Complete Labeling Reagent and Hybridization kit (Agilent Technologies) according to the manufacturer's instructions.

Reference

PMID: 20226005 Title: microRNA as a new immune-regulatory agent in breast milk Author: Kosaka N, Izumi H, Sekine K, Ochiya T. Journal: Silence. 2010 Mar 1;1(1):7. Description: BACKGROUND: Breast milk is a complex liquid that provides nutrition to the infant and facilitates the maturation of the infant's immune system. Recent studies indicated that microRNA (miRNA) exists in human body fluid. Because miRNAs are known to regulate various immune systems, we hypothesized that human breast milk contains miRNAs that may be important for the development of the infant's immune system.