exRNAdisease

Entry Detail

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General Information

Database ID: exR0358808 RNA Name: hsa-miR-155-5p RNA Type: miRNA Chromosome: chr21 Starnd: + Coordinate: Start Site(bp): 25573983 End Site(bp): 25574006 External Links: hsa-miR-155-5p

Disease Information

Disease Name: Newborn Infant Disease Category: Other Diseases MeSH ID: D007231 Type: Age Groups/Infant Alias: Infant, Newborn//Infants, Newborn//Newborn Infant//Newborn Infants//Newborns//Newborn//Neonate//Neonates

Expression Detail

GEO ID: GSE65203 Description: microRNA as a new immune-regulatory agent in breast milk Experimental Design: Disease vs Control Case Disease Type: Newborn Infant Case Disease SubType: NA Case Sample: Deliver < 28 days Control Sample: Deliver > 28 days Number of Case: 2 Number of Control: 4 Number of Samples: 6

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand TSC22D4 chr7 100463359 100479232 - ACOT7 chr1 6264269 6394391 - MRFAP1 chr4 6640091 6642745 + SH3KBP1 chrX 19533977 19887600 - NUFIP2 chr17 29255839 29294148 - CENPM chr22 41938737 41947152 - SP100 chr2 230415942 230545606 + ARL3 chr10 102673731 102714397 - JAK1 chr1 64833229 65067754 - LAPTM4A chr2 20032650 20051628 - SOD2 chr6 159669069 159745186 - HNRNPLL chr2 38561969 38603586 - LCP1 chr13 46125920 46211871 - AICDA chr12 8602170 8612867 - CD52 chr1 26317958 26320523 + MFSD9 chr2 102714630 102736888 - NDUFA4 chr7 10931943 10940153 - CHEK2 chr22 28687743 28742422 - ZMYM5 chr13 19823482 19863649 - PGLS chr19 17511636 17521288 + CCNB1 chr5 69167135 69178245 + IL2RG chrX 71107404 71112108 - CXXC1 chr18 50282343 50288304 - RBM38 chr20 57391396 57409333 + CFL1 chr11 65823022 65862026 - PPM1B chr2 44167969 44244384 + ZFP36 chr19 39406847 39409412 + FTL chr19 48965309 48966879 + ERH chr14 69380128 69398299 - VPS18 chr15 40894450 40903975 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000642 chr15 80390757 80415142 + hsa_circ_0000892 chr19 11941431 12014514 + hsa_circ_0001046 chr2 97024782 97033111 + hsa_circ_0000643 chr15 80412669 80415142 + hsa_circ_0000698 chr16 47531309 47549512 + hsa_circ_0001146 chr20 34241449 34246936 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC021078.1 chr5 149494314 149504670 - AC090198.1 chr8 124488510 124491643 + AC245033.4 chr15 82533175 82540008 - AL022311.1 chr22 37876148 37895563 + ELOA-AS1 chr1 23706901 23778296 - GABPB1-AS1 chr15 50354959 50372202 + LINC00240 chr6 26956932 27059749 + LINC01772 chr1 16460948 16468481 + MALAT1 chr11 65497688 65506516 + MIR155HG chr21 25561909 25575168 + MIR17HG chr13 91347820 91354579 + NORAD chr20 36045618 36051018 - OIP5-AS1 chr15 41283990 41309737 + SNHG5 chr6 85650491 85678932 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE65203 Sample Source: Breast Milk Source Fraction: Supernatant Platform: GPL7731 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 548 Sample treatment protocol: NA RNA Extract protocol: Total RNA extracted using mirVana miRNA isolation kit following manufacturer's instructions. RNA library preparation protocol: 70 ng of each RNA sample was labeled with the miRNA Complete Labeling Reagent and Hybridization kit (Agilent Technologies) according to the manufacturer's instructions.

Reference

PMID: 20226005 Title: microRNA as a new immune-regulatory agent in breast milk Author: Kosaka N, Izumi H, Sekine K, Ochiya T. Journal: Silence. 2010 Mar 1;1(1):7. Description: BACKGROUND: Breast milk is a complex liquid that provides nutrition to the infant and facilitates the maturation of the infant's immune system. Recent studies indicated that microRNA (miRNA) exists in human body fluid. Because miRNAs are known to regulate various immune systems, we hypothesized that human breast milk contains miRNAs that may be important for the development of the infant's immune system.