exRNAdisease

Entry Detail

---



General Information

Database ID: exR0358836 RNA Name: hsa-miR-193a-5p RNA Type: miRNA Chromosome: chr17 Starnd: + Coordinate: Start Site(bp): 31560016 End Site(bp): 31560037 External Links: hsa-miR-193a-5p

Disease Information

Disease Name: Newborn Infant Disease Category: Other Diseases MeSH ID: D007231 Type: Age Groups/Infant Alias: Infant, Newborn//Infants, Newborn//Newborn Infant//Newborn Infants//Newborns//Newborn//Neonate//Neonates

Expression Detail

GEO ID: GSE65203 Description: microRNA as a new immune-regulatory agent in breast milk Experimental Design: Disease vs Control Case Disease Type: Newborn Infant Case Disease SubType: NA Case Sample: Deliver < 28 days Control Sample: Deliver > 28 days Number of Case: 2 Number of Control: 4 Number of Samples: 6

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ADD1 chr4 2843857 2930076 + ANKRD13B chr17 29589769 29614761 + APPL2 chr12 105173297 105236203 - ARHGEF11 chr1 156934840 157045370 - ATP5F1D chr19 1241746 1244825 + CBFA2T3 chr16 88874858 88977207 - CRTC3 chr15 90529923 90645345 + E2F1 chr20 33675477 33686385 - FAM102A chr9 127940582 127980989 - LITAF chr16 11547722 11636381 - NR1D2 chr3 23945286 23980617 + SETD1A chr16 30957754 30984664 + SLC25A44 chr1 156193932 156212796 + SPRY4 chr5 142310427 142326455 - THUMPD1 chr16 20702816 20742084 - USP21 chr1 161159450 161165723 + ADSL chr22 40346500 40390463 + AL022238.4 chr22 40346529 40410054 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001805 chr8 68015271 68044315 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC239868.1 chr1 149861271 149862504 + SNHG16 chr17 76557764 76565348 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE65203 Sample Source: Breast Milk Source Fraction: Supernatant Platform: GPL7731 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 548 Sample treatment protocol: NA RNA Extract protocol: Total RNA extracted using mirVana miRNA isolation kit following manufacturer's instructions. RNA library preparation protocol: 70 ng of each RNA sample was labeled with the miRNA Complete Labeling Reagent and Hybridization kit (Agilent Technologies) according to the manufacturer's instructions.

Reference

PMID: 20226005 Title: microRNA as a new immune-regulatory agent in breast milk Author: Kosaka N, Izumi H, Sekine K, Ochiya T. Journal: Silence. 2010 Mar 1;1(1):7. Description: BACKGROUND: Breast milk is a complex liquid that provides nutrition to the infant and facilitates the maturation of the infant's immune system. Recent studies indicated that microRNA (miRNA) exists in human body fluid. Because miRNAs are known to regulate various immune systems, we hypothesized that human breast milk contains miRNAs that may be important for the development of the infant's immune system.