exRNAdisease

Entry Detail

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General Information

Database ID: exR0358837 RNA Name: hsa-miR-193b-3p RNA Type: miRNA Chromosome: chr16 Starnd: + Coordinate: Start Site(bp): 14304017 End Site(bp): 14304038 External Links: hsa-miR-193b-3p

Disease Information

Disease Name: Newborn Infant Disease Category: Other Diseases MeSH ID: D007231 Type: Age Groups/Infant Alias: Infant, Newborn//Infants, Newborn//Newborn Infant//Newborn Infants//Newborns//Newborn//Neonate//Neonates

Expression Detail

GEO ID: GSE65203 Description: microRNA as a new immune-regulatory agent in breast milk Experimental Design: Disease vs Control Case Disease Type: Newborn Infant Case Disease SubType: NA Case Sample: Deliver < 28 days Control Sample: Deliver > 28 days Number of Case: 2 Number of Control: 4 Number of Samples: 6

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AFAP1 chr4 7758714 7939926 - ANTXR1 chr2 69013178 69249327 + EHD1 chr11 64851642 64888296 - LASP1 chr17 38869859 38921770 + LUZP1 chr1 23084023 23177808 - NUDT21 chr16 56429133 56452199 - RUSC1 chr1 155320894 155331114 + TSPAN14 chr10 80454166 80533124 + ZBTB5 chr9 37438102 37465450 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001025 chr2 69565029 69565697 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC092295.2 chr19 36489649 36491040 + AC135050.6 chr16 31122235 31124064 + AL132780.1 chr14 22929607 22956374 + CYTOR chr2 87454781 87636740 + KCNQ1OT1 chr11 2608328 2699994 - LIMD1-AS1 chr3 45676369 45689200 - LINC01184 chr5 127939152 128083172 - MIR194-2HG chr11 64889560 64893449 - MIR4435-2HG chr2 111006015 111523376 - NEAT1 chr11 65422774 65445540 + XIST chrX 73820649 73852723 - ZFAS1 chr20 49278178 49299600 + Display:

Experiment Detail

GEO ID: GSE65203 Sample Source: Breast Milk Source Fraction: Supernatant Platform: GPL7731 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 548 Sample treatment protocol: NA RNA Extract protocol: Total RNA extracted using mirVana miRNA isolation kit following manufacturer's instructions. RNA library preparation protocol: 70 ng of each RNA sample was labeled with the miRNA Complete Labeling Reagent and Hybridization kit (Agilent Technologies) according to the manufacturer's instructions.

Reference

PMID: 20226005 Title: microRNA as a new immune-regulatory agent in breast milk Author: Kosaka N, Izumi H, Sekine K, Ochiya T. Journal: Silence. 2010 Mar 1;1(1):7. Description: BACKGROUND: Breast milk is a complex liquid that provides nutrition to the infant and facilitates the maturation of the infant's immune system. Recent studies indicated that microRNA (miRNA) exists in human body fluid. Because miRNAs are known to regulate various immune systems, we hypothesized that human breast milk contains miRNAs that may be important for the development of the infant's immune system.