exRNAdisease

Entry Detail

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General Information

Database ID: exR0358878 RNA Name: hsa-miR-25-3p RNA Type: miRNA Chromosome: chr7 Starnd: - Coordinate: Start Site(bp): 100093571 End Site(bp): 100093592 External Links: hsa-miR-25-3p

Disease Information

Disease Name: Newborn Infant Disease Category: Other Diseases MeSH ID: D007231 Type: Age Groups/Infant Alias: Infant, Newborn//Infants, Newborn//Newborn Infant//Newborn Infants//Newborns//Newborn//Neonate//Neonates

Expression Detail

GEO ID: GSE65203 Description: microRNA as a new immune-regulatory agent in breast milk Experimental Design: Disease vs Control Case Disease Type: Newborn Infant Case Disease SubType: NA Case Sample: Deliver < 28 days Control Sample: Deliver > 28 days Number of Case: 2 Number of Control: 4 Number of Samples: 6

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ADCY9 chr16 3953387 4116442 - ARMC1 chr8 65602458 65634217 - BCL9 chr1 147541501 147626216 + CCDC186 chr10 114120862 114174232 - CERK chr22 46684410 46738252 - EIF1AX chrX 20124525 20141838 - EML4 chr2 42169353 42332548 + FNBP4 chr11 47716494 47767443 - ITGAV chr2 186590056 186680901 + MRS2 chr6 24402908 24426194 + MTHFD2 chr2 74198610 74217565 + MYH9 chr22 36281277 36388067 - NFIB chr9 14081843 14398983 - NSMAF chr8 58583508 58659853 - PALLD chr4 168497052 168928457 + PPAT chr4 56393362 56435615 - PUS7 chr7 105439661 105522271 - RBFOX2 chr22 35738736 36028824 - RNF38 chr9 36336396 36487548 - RNF4 chr4 2462220 2625320 + RRN3 chr16 15060022 15094317 - SH3PXD2A chr10 103594027 103855543 - SOX4 chr6 21593751 21598619 + TXLNA chr1 32179675 32198285 + UBE2N chr12 93405673 93441947 - USP21 chr1 161159450 161165723 + XRN1 chr3 142306607 142448062 - TXNRD3 chr3 126607059 126655124 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001005 chr2 53921020 53978078 - hsa_circ_0001414 chr4 56277780 56284152 + hsa_circ_0000126 chr1 150997086 150999803 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC005394.2 chr19 28435388 28727680 - AC074117.1 chr2 27356246 27367622 + AC130650.2 chr16 14150833 14153235 + DAPK1-IT1 chr9 87553454 87554459 + LINC01128 chr1 825138 859446 + MALAT1 chr11 65497688 65506516 + NORAD chr20 36045618 36051018 - OIP5-AS1 chr15 41283990 41309737 + PITPNA-AS1 chr17 1516931 1518096 + PURPL chr5 27217714 27496994 + SNHG5 chr6 85650491 85678932 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE65203 Sample Source: Breast Milk Source Fraction: Supernatant Platform: GPL7731 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 548 Sample treatment protocol: NA RNA Extract protocol: Total RNA extracted using mirVana miRNA isolation kit following manufacturer's instructions. RNA library preparation protocol: 70 ng of each RNA sample was labeled with the miRNA Complete Labeling Reagent and Hybridization kit (Agilent Technologies) according to the manufacturer's instructions.

Reference

PMID: 20226005 Title: microRNA as a new immune-regulatory agent in breast milk Author: Kosaka N, Izumi H, Sekine K, Ochiya T. Journal: Silence. 2010 Mar 1;1(1):7. Description: BACKGROUND: Breast milk is a complex liquid that provides nutrition to the infant and facilitates the maturation of the infant's immune system. Recent studies indicated that microRNA (miRNA) exists in human body fluid. Because miRNAs are known to regulate various immune systems, we hypothesized that human breast milk contains miRNAs that may be important for the development of the infant's immune system.