exRNAdisease

Entry Detail

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General Information

Database ID: exR0358940 RNA Name: hsa-miR-34c-5p RNA Type: miRNA Chromosome: chr11 Starnd: + Coordinate: Start Site(bp): 111513451 End Site(bp): 111513473 External Links: hsa-miR-34c-5p

Disease Information

Disease Name: Newborn Infant Disease Category: Other Diseases MeSH ID: D007231 Type: Age Groups/Infant Alias: Infant, Newborn//Infants, Newborn//Newborn Infant//Newborn Infants//Newborns//Newborn//Neonate//Neonates

Expression Detail

GEO ID: GSE65203 Description: microRNA as a new immune-regulatory agent in breast milk Experimental Design: Disease vs Control Case Disease Type: Newborn Infant Case Disease SubType: NA Case Sample: Deliver < 28 days Control Sample: Deliver > 28 days Number of Case: 2 Number of Control: 4 Number of Samples: 6

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ZDHHC17 chr12 76763588 76853696 + PHF19 chr9 120855651 120894896 - CD151 chr11 832887 839831 + ATXN7L3 chr17 44191805 44200113 - TNRC6B chr22 40044817 40335808 + GATAD2B chr1 153789030 153923360 - SEC61A1 chr3 128051641 128071683 + NFAT5 chr16 69565094 69704666 + NPTX1 chr17 80466834 80477843 - TMEM109 chr11 60914158 60923443 + SUPT6H chr17 28662198 28702679 + ARPP19 chr15 52547045 52569883 - PXDC1 chr6 3722614 3752026 - TRIO chr5 14143342 14532128 + AGTRAP chr1 11736084 11754802 + NCOA1 chr2 24491914 24770702 + JRK chr8 142657460 142681968 - TOB2 chr22 41433494 41446801 - NFKBIA chr14 35401511 35404749 - ANGEL1 chr14 76786168 76826246 - MTMR9 chr8 11284816 11328146 + AMER1 chrX 64185117 64205708 - NECTIN1 chr11 119623408 119729200 - MRPL19 chr2 75646783 75690851 + IGSF3 chr1 116574399 116667755 - FOSL1 chr11 65892049 65900573 - TKFC chr11 61333210 61353295 + CRTC3 chr15 90529923 90645345 + FGFRL1 chr4 1009936 1026898 + ZIC5 chr13 99962964 99971909 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001723 chr7 91924202 91948826 + hsa_circ_0001495 chr5 68470703 68471364 + hsa_circ_0000943 chr19 47421744 47440665 + hsa_circ_0000038 chr1 28800065 28802803 + hsa_circ_0001865 chr9 86292641 86293514 - hsa_circ_0001146 chr20 34241449 34246936 - hsa_circ_0001164 chr20 45891031 45923523 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC018521.1 chr17 47945424 47981736 + AC116913.1 chr15 66488658 66492109 - HCG18 chr6 30286690 30327382 - KCNQ1OT1 chr11 2608328 2699994 - LINC00665 chr19 36313067 36331770 - NEAT1 chr11 65422774 65445540 + SNHG7 chr9 136721366 136728184 - TERC chr3 169764520 169765060 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE65203 Sample Source: Breast Milk Source Fraction: Supernatant Platform: GPL7731 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 548 Sample treatment protocol: NA RNA Extract protocol: Total RNA extracted using mirVana miRNA isolation kit following manufacturer's instructions. RNA library preparation protocol: 70 ng of each RNA sample was labeled with the miRNA Complete Labeling Reagent and Hybridization kit (Agilent Technologies) according to the manufacturer's instructions.

Reference

PMID: 20226005 Title: microRNA as a new immune-regulatory agent in breast milk Author: Kosaka N, Izumi H, Sekine K, Ochiya T. Journal: Silence. 2010 Mar 1;1(1):7. Description: BACKGROUND: Breast milk is a complex liquid that provides nutrition to the infant and facilitates the maturation of the infant's immune system. Recent studies indicated that microRNA (miRNA) exists in human body fluid. Because miRNAs are known to regulate various immune systems, we hypothesized that human breast milk contains miRNAs that may be important for the development of the infant's immune system.