exRNAdisease

Entry Detail

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General Information

Database ID: exR0358941 RNA Name: hsa-miR-361-3p RNA Type: miRNA Chromosome: chrX Starnd: - Coordinate: Start Site(bp): 85903641 End Site(bp): 85903663 External Links: hsa-miR-361-3p

Disease Information

Disease Name: Newborn Infant Disease Category: Other Diseases MeSH ID: D007231 Type: Age Groups/Infant Alias: Infant, Newborn//Infants, Newborn//Newborn Infant//Newborn Infants//Newborns//Newborn//Neonate//Neonates

Expression Detail

GEO ID: GSE65203 Description: microRNA as a new immune-regulatory agent in breast milk Experimental Design: Disease vs Control Case Disease Type: Newborn Infant Case Disease SubType: NA Case Sample: Deliver < 28 days Control Sample: Deliver > 28 days Number of Case: 2 Number of Control: 4 Number of Samples: 6

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ADD1 chr4 2843857 2930076 + ATP2A3 chr17 3923870 3964464 - C6orf89 chr6 36871870 36928964 + CBX2 chr17 79778148 79787983 + CCDC88C chr14 91271323 91417844 - CDC25B chr20 3786772 3806121 + CTDSP2 chr12 57819927 57846729 - CTSB chr8 11842524 11869448 - EGR1 chr5 138465479 138469303 + FOXP4 chr6 41546426 41602384 + HYOU1 chr11 119044188 119057227 - IGF2BP1 chr17 48997385 49056145 + NACC1 chr19 13116862 13141147 + NPTN chr15 73560014 73634134 - PRMT1 chr19 49675786 49689029 + SH2B1 chr16 28846600 28874212 + SPTBN2 chr11 66685248 66729226 - TNFAIP3 chr6 137867214 137883312 + UBTF chr17 44205033 44221626 - VCL chr10 73995193 74121363 + ZBTB7A chr19 4043303 4066899 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000921 chr19 30476129 30477324 + hsa_circ_0000032 chr1 25666964 25669564 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC016876.2 chr17 7581964 7584086 - AC092127.1 chr16 85592266 85595720 + KCNQ1OT1 chr11 2608328 2699994 - MALAT1 chr11 65497688 65506516 + NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - SNHG1 chr11 62851984 62855953 - Display:

Experiment Detail

GEO ID: GSE65203 Sample Source: Breast Milk Source Fraction: Supernatant Platform: GPL7731 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 548 Sample treatment protocol: NA RNA Extract protocol: Total RNA extracted using mirVana miRNA isolation kit following manufacturer's instructions. RNA library preparation protocol: 70 ng of each RNA sample was labeled with the miRNA Complete Labeling Reagent and Hybridization kit (Agilent Technologies) according to the manufacturer's instructions.

Reference

PMID: 20226005 Title: microRNA as a new immune-regulatory agent in breast milk Author: Kosaka N, Izumi H, Sekine K, Ochiya T. Journal: Silence. 2010 Mar 1;1(1):7. Description: BACKGROUND: Breast milk is a complex liquid that provides nutrition to the infant and facilitates the maturation of the infant's immune system. Recent studies indicated that microRNA (miRNA) exists in human body fluid. Because miRNAs are known to regulate various immune systems, we hypothesized that human breast milk contains miRNAs that may be important for the development of the infant's immune system.