exRNAdisease

Entry Detail

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General Information

Database ID: exR0358954 RNA Name: hsa-miR-374b-5p RNA Type: miRNA Chromosome: chrX Starnd: - Coordinate: Start Site(bp): 74218587 End Site(bp): 74218608 External Links: hsa-miR-374b-5p

Disease Information

Disease Name: Newborn Infant Disease Category: Other Diseases MeSH ID: D007231 Type: Age Groups/Infant Alias: Infant, Newborn//Infants, Newborn//Newborn Infant//Newborn Infants//Newborns//Newborn//Neonate//Neonates

Expression Detail

GEO ID: GSE65203 Description: microRNA as a new immune-regulatory agent in breast milk Experimental Design: Disease vs Control Case Disease Type: Newborn Infant Case Disease SubType: NA Case Sample: Deliver < 28 days Control Sample: Deliver > 28 days Number of Case: 2 Number of Control: 4 Number of Samples: 6

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand IPO8 chr12 30628988 30695869 - PLEKHB2 chr2 131104847 131353709 + ATP5F1C chr10 7788147 7807815 + CCT6A chr7 56051685 56063989 + DLGAP5 chr14 55148112 55191608 - DSG2 chr18 31498177 31549008 + FZD6 chr8 103298433 103332866 + GPD1L chr3 32105689 32168713 + GSR chr8 30678066 30727846 - MPP5 chr14 67241342 67336061 + PRKCI chr3 170222424 170305977 + USP1 chr1 62436297 62451804 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC010327.5 chr19 55216660 55221616 + AC093010.3 chr3 114314501 114329714 - AL022311.1 chr22 37876148 37895563 + EBLN3P chr9 37079645 37090928 + GAS5 chr1 173858559 173868882 - LINC01184 chr5 127939152 128083172 - MALAT1 chr11 65497688 65506516 + NEAT1 chr11 65422774 65445540 + OIP5-AS1 chr15 41283990 41309737 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE65203 Sample Source: Breast Milk Source Fraction: Supernatant Platform: GPL7731 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 548 Sample treatment protocol: NA RNA Extract protocol: Total RNA extracted using mirVana miRNA isolation kit following manufacturer's instructions. RNA library preparation protocol: 70 ng of each RNA sample was labeled with the miRNA Complete Labeling Reagent and Hybridization kit (Agilent Technologies) according to the manufacturer's instructions.

Reference

PMID: 20226005 Title: microRNA as a new immune-regulatory agent in breast milk Author: Kosaka N, Izumi H, Sekine K, Ochiya T. Journal: Silence. 2010 Mar 1;1(1):7. Description: BACKGROUND: Breast milk is a complex liquid that provides nutrition to the infant and facilitates the maturation of the infant's immune system. Recent studies indicated that microRNA (miRNA) exists in human body fluid. Because miRNAs are known to regulate various immune systems, we hypothesized that human breast milk contains miRNAs that may be important for the development of the infant's immune system.